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Pacemaker optimization guided by echocardiography in cardiac resynchronization therapy

Trifunović Danijela (Kabinet za ehokardiografiju, Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Petrović Milan (Kabinet za ehokardiografiju, Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Milašinović Goran (Pejsmejker centar, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Vujisić-Tešić Bosiljka (Kabinet za ehokardiografiju, Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Boričić Marija (Kabinet za ehokardiografiju, Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Nedeljković Ivana (Kabinet za ehokardiografiju, Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Jelić Vera (Pejsmejker centar, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Živković Mirjana (Pejsmejker centar, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Jovanović Velibor (Pejsmejker centar, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Petrović Olga (Kabinet za ehokardiografiju, Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Banović Marko (Kabinet za ehokardiografiju, Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Nikčević Gabrijala (Kabinet za ehokardiografiju, Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Ostojić Miodrag (Kabinet za ehokardiografiju, Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)

Introduction. Cardiac resynchronization therapy (CRT) or biventricular pacing is a contemporary treatment in the management of advanced heart failure. Echocardiography plays an evolving and important role in patient selection for CRT, follow-up of acute and chronic CRT effects and optimization of device settings after biventricular pacemaker implantation. In this paper we illustrate usefulness of echocardiography for successful AV and VV timing optimization in patients with CRT. A review of up-to-date literature concerning rationale for AV and VV delay optimization, echocardiographic protocols and current recommendations for AV and VV optimization after CRT are also presented. Outline of Cases. The first case is of successful AV delay optimization guided by echocardiography in a patient with dilated cardiomyopathy treated with CRT is presented. Pulsed blood flow Doppler was used to detect mitral inflow while programming different duration of AV delay. The AV delay with optimal transmittal flow was established. The optimal mitral flow was the one with clearly defined E and A waves and maximal velocity time integral (VTI) of the mitral flow. Improvement in clinical status and reverse left ventricle remodelling with improvement of ejection fraction was registered in our patient after a month. The second case presents a patient with heart failure caused by dilated cardiomyopathy; six months after CRT implantation the patient was still NYHA class III and with a significantly depressed left ventricular ejection fraction. Optimization of VV interval guided by echocardiography was undertaken measuring VTI of the left ventricular outflow tract (LVOT) during programming of different VV intervals. The optimal VV interval was determined using a maximal LVOT VTI. A month after VV optimization our patient showed improvement in LV ejection fraction. Conclusion. Optimal management of patients treated with CRT integrate both clinical and echocardiographic follow-up with, if needed, echocardiographically guided optimization of AV and VV delays, which offers the possibility of additional clinical improvement in such patients.

Keywords: heart failure, resynchronization therapy, optimization