doiSerbia

Arias icterus: Prolonged unconjugated hyperbilirubinemia caused by breast milk

Mladenović Marija (Zdravstveni centar, Valjevo)
Radlović Nedeljko (Univerzitetska dečja klinika, Beograd)
Ristić Dragana (Univerzitetska dečja klinika, Beograd)
Leković Zoran (Univerzitetska dečja klinika, Beograd)
Radlović Petar (Institut za onkologiju i radiologiju Srbije, Beograd)
Pavlović Momčilo (Dečje odeljenje, Opšta bolnica, Subotica)
Gajić Milan (Institut za medicinsku statistiku i informatiku, Medicinski fakultet, Beograd)
Puškarević Marijana (Univerzitetska dečja klinika, Beograd)
Davidović Ivana (Univerzitetska dečja klinika, Beograd)
Đurđević Jelena (Dom zdravlja 'Stari grad', Beograd)

Introduction Breast milk jaundice occurs in 1-2% of healthy breast-fed newborns and young infants. It develops as the result of liver immaturity and the inhibitory effect of mother’s milk to the clearance of unconjugated bilirubin. Objective The paper analyzes variations in the level and length of unconjugated hyperbilirubinemia in breast-fed infants. Method The study was conducted on a sample of 29 young infants (19 male) with breast milk jaundice. All infants were born on time, by natural delivery and without complications. All were on breast-feeding only and developed optimally. None of the infants had either haemolysis or any other disease associated with unconjugated hyperbilirubinemia. Results All infants had physiological jaundice in the first week after birth, with unconjugated bilirubin level of 166-260 μmol (201.50±36.37 μmol). In the postneonatal period the highest bilirubin level was recorded in the fifth week of life and was 87-273 μmol (166.82±45.06 μmol), which then spontaneously, without interruption of breast-feeding, gradually declined. The decrease of the unconjugated fraction of serum bilirubin between the fourth and fifth week was significant, and after that highly significant. The normalization of serum bilirubin occurred in the seventh and thirteenth week (10.41±1.68 μmol). Negative consequences of hyperbilirubinemia were not noted in any of the infants. Conclusion Breast milk jaundice presents a harmless and transitory disorder of bilirubin metabolism. It occurs in healthy breast-fed neonates and young infants. Jaundice is most marked in early neonatal period, and then it gradually declines and disappears between the seventh and thirteenth week.

Keywords: unconjugated hyperbilirubinemia, breast-feeding, liver immaturity