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Srpski arhiv za celokupno lekarstvo 2005 Volume 133, Issue 5-6, Pages: 258-261
https://doi.org/10.2298/SARH0506258B
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HIV infection and the kidneys, Part II: Morphologic changes and their diagnostic significance

Basta-Jovanović Gordana M. (Institut za patologiju, Medicinski fakultet, Univerzitet u Beogradu, Beograd)
Radojević Sanja M. (Institut za patologiju, Medicinski fakultet, Univerzitet u Beogradu, Beograd)
Savin Marina (Institut za nefrologiju i urologiju, Klinički centar Srbije, Beograd)
Terzić Tatjana ORCID iD icon (Institut za patologiju, Medicinski fakultet, Univerzitet u Beogradu, Beograd)
Nenadović Maja (Institut za patologiju, Medicinski fakultet, Univerzitet u Beogradu, Beograd)
Stojimirović Biljana (Institut za nefrologiju i urologiju, Klinički centar Srbije, Beograd)
Škodrić Stevo (Institut za patologiju, Medicinski fakultet, Univerzitet u Beogradu, Beograd)
Nešić Vidosava (Institut za nefrologiju i urologiju, Klinički centar Srbije, Beograd)
Dikman Steve (Department of Pathology, Mount Sinai School of Medicine, New York)

HIV-infected patients may be faced with a variety of renal problem patterns. HIV-associated nephropathy is a unique pattern of sclerosing glomerulopathy and represents the most rapidly progressive form of focal segmental glomerulosclerosis. This study involved the examination of 32 renal biopsies: by light, immunofluorescence, and electron microscopy, in order to determine the most accurate and reliable diagnostic procedure. The findings show that the most sensitive and accurate procedure is electron microscopy, capable of detecting specific EM changes very early on, which is sufficient for the diagnosis of HIV-associated nephropathy.

Keywords: HIV-associated nephropathy, AIDS, focal segmental glomerulosclerosis, electron microscopy

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