doiSerbia

Pathophysiological aspects of severe acute pancreatitis-associated lung injury

Šurbatović Maja (Klinika za anesteziologiju i intenzivnu terapiju, Vojnomedicinska akademija, Beograd)
Jovanović Krsta (Klinika za anesteziologiju i intenzivnu terapiju, Vojnomedicinska akademija, Beograd)
Radaković Sonja (Zavod za preventivnu medicinu, Vojnomedicinska akademija, Beograd)
Filipović Nikola (Klinika za anesteziologiju i intenzivnu terapiju, Vojnomedicinska akademija, Beograd)

Acute pancreatitis is an inflammatory process which occurs in severe form in 20% of all patients, out of whom 1596-25% will die. The incidence of severe acute pancreatitis-associated lung injury (APALI) varies from 15% to 55% and its severity varies from mild hypoxemia to acute respiratory distress syndrome (ARDS). Acute lung injury (ALI) and ARDS are the most significant manifestations of extra abdominal dysfunctions in severe acute pancreatitis with mortality rate as high as 60% in the first week of the onset of illness. Different pathophysiological mechanisms of severe acute pancreatitis-associated lung injury have been described. The role of enzymes, adhesion molecules, neutrophils, fibronectin and various inflammatory mediators has been emphasized. Mechanism of the acute lung injury associated with the acute pancreatitis is very complex and has not been clear yet. There is no specific therapeutic procedure and mortality rate is very high. Therefore, further studies are necessary to address this acute and growing problem in intensive medicine.

Keywords: acute lung injury, acute pancreatitis, pathophysiology