doiSerbia

Proteinuria: The diagnostic strategy based on urine proteins differentiation

Stojimirović Biljana B. (Institut za urologiju i nefrologiju, Klinika za nefrologiju, Klinički centar Srbije, Beograd)
Petrović Dejan (Klinika za urologiju i nefrologiju, KBC „Kragujevac', Kragujevac)

Basal glomerular membrane represents mechanical and electrical barrier for passing of the plasma proteins. Mechanical barrier is composed of cylindrical pores and filtration fissure, and negative layer charge in exterior and interior side of basal glomerular membrane, made of heparan sulphate and sialoglicoproteine, provides certain electrical barrier. Diagnostic strategy based on different serum and urine proteins enables the differentiation of various types of proteinuria. Depending on etiology of proteinuria it can be prerenal, renal and postrenal. By analyzing albumin, armicroglobulin, immunoglobulin G and armacroglobulin, together with total protein in urine, it is possible to detect and differentiate causes of prerenal, renal (glomerular, tubular, glomerulo-tubular) and postrenal proteinuria. The adequate and early differentiation of proteinuria type is of an immense diagnostic and therapeutic importance.

Keywords: proteinuria, armicroglobulin, albumin, immunoglobulin G, armacroglobulin, cystatine C, diagnostic strategy