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Intravascular lymphomatosis of central nervious system - case report

Jović Jasmina (Zdravstveni centar 'Dr Radivoj Simonović', Sombor)
Ercegovac Marko (Odeljenje urgentne neurologije, Institut za neurologiju, Klinički centar Srbije, Beograd)
Dožić Branko (Institut za patologiju, Klinički centar Srbije, Beograd)
Cvetković Dubravka (Institut za patologiju, Klinički centar Srbije, Beograd)
Živković Miroslava (Klinika za neurologiju, Klinički centar, Niš)
Beslać-Bumbaširević Ljiljana G. (Odeljenje urgentne neurologije, Institut za neurologiju, Klinički centar Srbije, Beograd)

Intravascular lymphomatosis is an uncommon lymphoproliferative disorder characterised by intravascular distribution of neoplastic lymphoid cells (B- or T- lymphocites), what leads to occlusion of small vessels and causes signs and simptoms of disorder. Its initial predilection sites are the brain or the skin, and hematopoetic organs are usually spared. The signs and symptoms of the disorder are attributed to vascular occlusion. Clinical course is fatal, besides therapy. In our case disorder has started with partial epileptic seizures with secondary generalisation, and after that with motor aphasia, right hemi paresis, urinary incontinence and cognitive changes. She was hospitalized for several times, completely investigated, but with no conclusion. Seven months after appearance of symptoms, she died. And diagnosis was determined at autopsy. A myriad of neurological and systemic manifestations are putting us in an unequal position with this fatal disease. Early diagnosis can increase survival and decrease intensity of symptoms. So every new case is important as warning that we must not forget about this disease.

Keywords: intravascular lymphomatosis, B-lymphocites, central nervious system