doiSerbia

Adhesion molecules in Wilms tumor (part II) : beta-catenin expression and significance

Basta-Jovanović Gordana M. (Institut za patologiju Medicinskog fakulteta u Beogradu)
Radojević Sanja M. (Institut za patologiju Medicinskog fakulteta u Beogradu)
Đuričić Slaviša M. (Institut za zdravstvenu zaštitu majke i deteta Srbije 'Dr Vukan Čupić')
Savin Marina (Institut za nefrologiju i urologiju KBC Srbije)
Škodrić Stevo (Institut za patologiju Medicinskog fakulteta u Beogradu)
Bunjevački Gordana (Institut za zdravstvenu zaštitu majke i deteta Srbije 'Dr Vukan Čupić')
Hadži-Đokić Jovan B. (Institut za nefrologiju i urologiju KBC Srbije)
Nešić Vidosava B. (Institut za nefrologiju i urologiju KBC Srbije)

Beta-catenin is a glicoprotein which has an important role in cell-cell adhesion, as well as in cell signal transmition, in u regulation of gen expression and in interaction with axin and APC (adenomatous poliposis coli). Its oncogenic role in several types of carcinomas in human population is well known. It is very likely that b-catenin as an protooncogen plays an importante role in genesis of Wilms tumor. It is well known that in 15% Wilms tumors there are b-catenin mutations, which indicates that there is a disorder in Wnt signal paththat plays an important role in Wilms tumor genesis. The aim of our study was to investigate b-catenin expression in Wilms tumor, to compaire it with the expression in normal renal tissue as well as to see if there is a positive correlation between b-catenin expression in Wilms tumor with tumor stage, histologic type and/ or prognostic group.

Keywords: Wilms tumor, adhesion molecules, b- catenin