doiSerbia

Adhesion molecules in Wilms tumor (part I)

Basta-Jovanović Gordana M. (Institut za patologiju Medicinskog fakulteta u Beogradu)
Radojević Sanja M. (Institut za patologiju Medicinskog fakulteta u Beogradu)
Đuričić Slaviša M. (Institut za zdravstvenu zaštitu majke i deteta Srbije 'Dr Vukan Čupić')

Adhesion molekues are glicoprotees which have extracellular, transmembranous and intracytoplasmatic part. They show their basic role is in cell interaction in the tissue on one side and between cells and matrix on the other side. They have an important role in stabile integrity of tumor tissue, as well as in differenciation, prolifferation, apoptosis and metastatic spread of tumorous cells. Since there is very little known facts about adhesion molecule detection and about its significance in Wilms tumor, our intention was to collect all known achievements which could be of importance for better understanding of tumors nature and successful treatment. Especially because of well known fact that in 15% Wilms tumors there are b-catenin mutations, which indicates that there is a disorder in Wnt signal paththat plays an important role in Wilms tumor genesis.

Keywords: Wilms tumor, adhesion molecules, integrins, selectins, immunoglobilie supergen family, cadherins, catenins