doiSerbia

Endoskopija u dijagnostici i lečenju inoperabilnog karcinoma jednjaka nakon radioterapije i kombinovane radiohemioterapije

Josifovski Jeremija (Institut za onkologiju i radiologiju Srbije, Beograd)
Radošević-Jelić Ljiljana M. (Institut za onkologiju i radiologiju Srbije, Beograd)

Treatment of inoperable (locally advanced) esophagus cancer, even today, has been a subject of numerous clinical researches. Combination of several clinical modalities is needed, of radiotherapy and chemotherapy the most frequently. This combination applied as neoadjuvant or concomitant brought to improvement of treatment results of these patients. Local control is still a big problem, since majority of these patients die of local treatment "failure". Because of that, estimation of the local control is very important, ie. assessment of the tumor response the treatment. For those reasons, a study has been conducted on 52 patients with locally advanced esophagus tumor, who in the first group of 25 patients, were treated only by radiotherapy, and in the second group of 27 patients, by combined radio-chemotherapy. Pretherapy evaluation, evaluation of esophagus stenosis as well as the tumor regression to conducted treatment, were done in all patients by radiography and endoscopy and the findings were compared: there was no statistically significant difference between investigated methods (p>0.05). although bigger number of the tumor complete regressions was verified by radiography (6 in the first group and 5 in the second group of patients) in relation to endoscopic finding (3 in the first group and 2 in the second group of patients), which had no microscopical evidence of remaining disease. Partial tumor regression made greater differences between investigated methods (10:4 in the first group and 6:3 in the second group of patients).

Keywords: Endoscopy, Esophagus neoplasma, Tumor response