doiSerbia

Analysis of donor selection for living related kidney transplantation and their postoperative outcome

Ležaić Višnja (Institut za urologiju i nefrologiju Klinike za nefrologiju Kliničkog centra Srbije, Beograd)
Đukanović Ljubica D. (Institut za urologiju i nefrologiju Klinike za nefrologiju Kliničkog centra Srbije, Beograd)
Radivojević-Đokić Dragana (Institut za urologiju i nefrologiju Klinike za nefrologiju Kliničkog centra Srbije, Beograd)
Blagojević-Lazić Radmila (Institut za urologiju i nefrologiju Klinike za nefrologiju Kliničkog centra Srbije, Beograd)
Ristić Stojanka (Institut za urologiju i nefrologiju Klinike za nefrologiju Kliničkog centra Srbije, Beograd)
Dokić Željka (Institut za urologiju i nefrologiju Klinike za nefrologiju Kliničkog centra Srbije, Beograd)
Stojković Dragiša (Institut za urologiju i nefrologiju Klinike za nefrologiju Kliničkog centra Srbije, Beograd)

Lack of cadaveric organs for transplantation resulted in increased number of living related kidney donors examinations and consequent transplantations in our Department. Donor procedure, selection, drop-outs and final results for living related donors (LRD) were retrospectively analyzed in this paper. Between 1987 and 1994 202 potential LRD were examined. Most of them were females (59%) and about 30% were older than 60 years. The family relation between LRD and recipients were: parents (95%), siblings (3%), grandmother grandfather (1.5%) and uncle (0.5%). Potential LRD were informed on risks advantages and procedure of living donor transplantation. After primary information 26% of potential LRD gave up further examinations. Following immunological and clinical evaluations 48% of LRD actually donated a kidney. The other 26% were excluded during the selection procedure. High immunological risks including ABO incompatibility, HLA mismatches and positive cross match test were the reasons for drop outs of 35 potential LRD (17%). Five more donors were excluded for medical reasons: one because of low creatinine clearance and four because of neoplasms, discovered during examination (kidney, laryngeal, lung). Fourteen transplantation were not realized due to different recipient reasons: 5 of them had clinical contraindications, two died and in 7 cadaveric kidney transplantations were performed. Mild hypertension, coronary disease and diabetes mellitus type 2 were presented in 5 LRD accepted for transplantation. Five more had to be operated before donation (abdominal or urological operation). Early complications after donor nephrectomy were acute renal failure, stress ulcus, pleuropneumonia in three and thromboflebitis in two donors. In conclusion, although kidney transplantation from LRD is highly successful careful examination during selection procedure is indispensable.

Keywords: living kidney donor, selection, follow-up