doiSerbia

The influence of proteinuria on tubular transport of Na+, K+, CL

Petrović Dejan (Klinika za urologiju i nefrologiju Kliničko-bolničkog centra 'Kragujevac', Kragujevac)
Obrenović Radmila (Institut za medicinsku biohemiju Kliničkog centra Srbije, Beograd)
Poskurica Mileta (Klinika za urologiju i nefrologiju Kliničko-bolničkog centra 'Kragujevac', Kragujevac)
Stojimirović Biljana B. (Institut za urologiju i nefrologiju Kliničkog centra Srbije, Beograd)

Functional and structural damages of tubulointerstitium are caused by proteinuria. The aim of this study was to assess the influence of different proteinuria levels on Na+, K+, Cl tubular transport. We examined 50 patients (24 males, 26 females), mean age 46.50 ± 13.08 years, with mean creati-nine clearence of 87.29 ± 31.17 mL/min. They were separated in three groups depending on proteinuria value. The first group with proteinuria less than 0.3 g/24h included 19 persons (7 males, 12 females), mean age 45.12 ± 13.28 years, with mean creatinine clearance of 94.27 ± 34.70 mL/min. The second group of 18 patients (8 males, 10 females), mean age 45.39 ± 12.64 years had proteinuria of 0.3-3,0 g/24h and mean creatinine clearance of 90.07 ± 31.89 mL/min. The third group had proteinuria level higher than 3.0g/24h and mean creatinine clearance of 73.25 ± 20.44 mL/min. It included 13 patients (9 males, 4 females), mean age 50.08 ± 13.73 years. As a parameter of proteinuria influence on tubular transport of Na+, K+ and Cl-, fractional excretion of these electrolytes, was studied. Student's T test, Mann Whitney U test and c2 test were used for statistical analysis. No statistically significant influence of proteinuria was found on Na+, K+ and Cl tubular transport.

Keywords: Proteinuria, tubular function, fractional excretion of electrolyte