doiSerbia

Screening of mutations and polymorphism in CFRT gene in men infertile due to oligo- or azospermia

Kušić Jelena S. (Institut za molekularnu genetiku i genetičko inženjerstvo, Beograd)
Radojković Dragica P. (Institut za molekularnu genetiku i genetičko inženjerstvo, Beograd)
Maletić-Vukotić Vinka D. (Urološka klinika Kliničkog centra Srbije, Beograd)
Branković Snežana (Institut za mentalno zdravlje, Beograd)
Savić Ana P. (Institut za molekularnu genetiku i genetičko inženjerstvo, Beograd)

We concluded that CFTR gene plays a role in the etiology of obstructive azoospermia and that it also could be involved in same cases of impaired spermatogenesis and sperm maturation. Due to the high incidence of CFRT mutations in patients with obstructive azoospermia we suggest screening of CFRT mutations before assisted reproduction.

Keywords: CFTR gene, oligospermia, azoospermia, male infertility