Chemical Industry and Chemical Engineering Quarterly 2012 Volume 18, Issue 4-2, Pages: 653-659
https://doi.org/10.2298/CICEQ120113113S
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Application of profluorescent nitroxides for measurements of oxidative capacity of combustion generated particles
Stevanovic S. (International Laboratory for Air Quality and Health, Queensland University of Technology, Australia + ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Queensland University of Technology, Australia)
Ristovski Z.D. (International Laboratory for Air Quality and Health, Queensland University of Technology, Australia)
Miljevic B. (International Laboratory for Air Quality and Health, Queensland University of Technology, Australia)
Fairfull-Smith K.E. (ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Queensland University of Technology, Australia)
Bottle S.E. (ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Queensland University of Technology, Australia)
Oxidative stress caused by generation of free radicals and related reactive
oxygen species (ROS) at the sites of deposition has been proposed as a
mechanism for many of the adverse health outcomes associated with exposure to
particulate matter (PM). Recently, a new profluorescent nitroxide molecular
probe (BPEAnit) developed at QUT was applied in an entirely novel, rapid and
non-cell based assay for assessing the oxidative potential of particles (i.e.
potential of particles to induce oxidative stress). The technique was applied
on particles produced by several combustion sources, namely cigarette smoke,
diesel exhaust and wood smoke. One of the main findings from the initial
studies undertaken at QUT was that the oxidative potential per PM mass
significantly varies for different combustion sources as well as the type of
fuel used and combustion conditions. However, possibly the most important
finding from our studies was that there was a strong correlation between the
organic fraction of particles and the oxidative potential measured by the PFN
assay, which clearly highlights the importance of organic species in
particle-induced toxicity.
Keywords: combustion particles, diesel particles (DPM), oxidative stress, reactive oxygen species (ROS)