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Rebaudioside A Loaded Poly-D,L-Lactide-Nanoparticles as an Anti-Diabetic Nanomedicine

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Rebaudioside A is a major constituent (20% w/w) of natural stevioside powder and possess strong insulinotropic (anti-diabetic) activity with an extra glucose molecule than stevioside. In this manuscript, we have reported the nanofabrication of pure rebaudioside A and its effect on size, encapsulation efficiency and in vitro release. These results have been compared with stevioside nanoparticles using same synthesis process to evaluate the effect of extra glycosylation on nanoencapsulation (Colloids and surfaces B: Biointerfaces, 101 (2013) 510–516). Mono-disperse rebaudioside A-PLA nanoparticles of larger size (150–200 nm) than stevioside NPs (110–130 nm) were obtained along with 28.57% molecular loading efficiency (w/w%). However, rebaudioside A-PLA nanoparticle shows similar in vitro burst and sustained release upto 200 h as nano-stevioside. This study reveals that rebaudioside A-PLA nanoparticles can be used as a better antidiabetic nanomedicine than previously reported stevioside PLA nanoparticles.

Keywords: ANTI-DIABETIC; IN VITRO RELEASE; NANOENCAPSULATION; NANOMEDICINE; REBAUDIOSIDE A

Document Type: Research Article

Publication date: 01 April 2014

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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