Issue 26, 2016

Non-covalent adsorption of amino acid analogues on noble-metal nanoparticles: influence of edges and vertices

Abstract

The operation of many nanostructured biomolecular sensors and catalysts critically hinges on the manipulation of non-covalent adsorption of biomolecules on unfunctionalised noble-metal nanoparticles (NMNPs). Molecular-level structural details of the aqueous biomolecule/NMNP interface are pivotal to the successful realisation of these technologies, but such experimental data are currently scarce and challenging to obtain. Molecular simulations can generate these details, but are limited by the assumption of non-preferential adsorption to NMNP features. Here, via first principles calculations using a vdW-DF functional, and based on nanoscale sized NMNPs, we demonstrate that adsorption preferences to NP features vary with adsorbate chemistry. These results show a clear distinction between hydrocarbons, that prefer adsorption to facets over edges/vertices, over heteroatomic molecules that favour adsorption onto vertices over facets. Our data indicate the inability of widely used force-fields to correctly capture the adsorption of biomolecules onto NMNP surfaces under aqueous conditions. Our findings introduce a rational basis for the development of new force-fields that will reliably capture these phenomena.

Graphical abstract: Non-covalent adsorption of amino acid analogues on noble-metal nanoparticles: influence of edges and vertices

Supplementary files

Article information

Article type
Paper
Submitted
08 Apr 2016
Accepted
01 Jun 2016
First published
01 Jun 2016

Phys. Chem. Chem. Phys., 2016,18, 17525-17533

Non-covalent adsorption of amino acid analogues on noble-metal nanoparticles: influence of edges and vertices

Z. E. Hughes and T. R. Walsh, Phys. Chem. Chem. Phys., 2016, 18, 17525 DOI: 10.1039/C6CP02323A

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