Issue 56, 2016
From the journal:

Chemical Communications

Using steric bulk for selective recognition; blocking the binding site to differentiate guests†

Ryan N. Robsona  and  Frederick M. Pfeffer*a  

* Corresponding authors

a Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, Victoria, Australia
E-mail: fred.pfeffer@deakin.edu.au

Abstract

Selectivity is demonstrated in a supramolecular host:guest system using a receptor with a non-linear binding site. For the “open” receptor 1 strong binding for both flexible and rigid guests was observed. Receptor 2, with a “blocked” binding site, also bound flexible guests effectively but its affinity for rigid guests was 50 fold lower.

Graphical abstract: Using steric bulk for selective recognition; blocking the binding site to differentiate guests

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Article information

DOI
https://doi.org/10.1039/C6CC04549A
Article type
Communication
Submitted
31 May 2016
Accepted
16 Jun 2016
First published
16 Jun 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 8719-8721

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Using steric bulk for selective recognition; blocking the binding site to differentiate guests

R. N. Robson and F. M. Pfeffer, Chem. Commun., 2016, 52, 8719 DOI: 10.1039/C6CC04549A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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