Issue 45, 2016
From the journal:

Chemical Communications

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers†

Mark D. Tarn,‡ab   Dzmitry Maneuski,‡*c   Richard Alexander,§d   Nathaniel J. Brown,d   Val O’Shea,c   Sally L. Pimlott,e   Nicole Pamme*b  and  Stephen J. Archibald*ab  

* Corresponding authors

a Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, UK
E-mail: s.j.archibald@hull.ac.uk
Fax: +44 (0)1482 466410
Tel: +44 (0)1482 465488

b Department of Chemistry, University of Hull, Cottingham Road, Hull, UK
E-mail: n.pamme@hull.ac.uk
Fax: +44 (0)1482 466410
Tel: +44 (0) 1482 465027

c School of Physics and Astronomy, University of Glasgow, Glasgow, UK
E-mail: dima.maneuski@glasgow.ac.uk

d School of Engineering, University of Hull, Cottingham Road, Hull, UK

e School of Medicine, University of Glasgow, Glasgow, UK

Abstract

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [68Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.

Graphical abstract: Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC00660D
Article type
Communication
Submitted
22 Jan 2016
Accepted
16 Mar 2016
First published
16 Mar 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 7221-7224

Author version available

Download author version (PDF)

Permissions

Request permissions

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

M. D. Tarn, D. Maneuski, R. Alexander, N. J. Brown, V. O’Shea, S. L. Pimlott, N. Pamme and S. J. Archibald, Chem. Commun., 2016, 52, 7221 DOI: 10.1039/C6CC00660D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements