Issue 9, 2014
From the journal:

Lab on a Chip

Microfluidic platforms for biomarker analysis†

Sofia Nahavandi,*a   Sara Baratchi,bc   Rebecca Soffe,c   Shi-Yang Tang,c   Saeid Nahavandi,d   Arnan Mitchellc  and  Khashayar Khoshmanesh*c  

* Corresponding authors

a Faculty of Medicine, Dentistry, & Health Sciences, The University of Melbourne, VIC 3010, Australia
E-mail: sofia.nahavandi@gmail.com

b Health Innovations Research Institute, RMIT University, VIC 3083, Australia

c School of Electrical and Computer Engineering, RMIT University, VIC 3001, Australia
E-mail: khashayar.khoshmanesh@rmit.edu.au

d Centre for Intelligent Systems Research, Deakin University, VIC 3216, Australia

Abstract

Biomarkers have been described as characteristics, most often molecular, that provide information about biological states, whether normal, pathological, or therapeutically modified. They hold great potential to assist diagnosis and prognosis, monitor disease, and assess therapeutic effectiveness. While a few biomarkers are routinely utilised clinically, these only reflect a very small percentage of all biomarkers discovered. Numerous factors contribute to the slow uptake of these new biomarkers, with challenges faced throughout the biomarker development pipeline. Microfluidics offers two important opportunities to the field of biomarkers: firstly, it can address some of these developmental obstacles, and secondly, it can provide the precise and complex platform required to bridge the gap between biomarker research and the biomarker-based analytical device market. Indeed, adoption of microfluidics has provided a new avenue for advancement, promoting clinical utilisation of both biomarkers and their analytical platforms. This review will discuss biomarkers and outline microfluidic platforms developed for biomarker analysis.

Graphical abstract: Microfluidic platforms for biomarker analysis

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Article information

DOI
https://doi.org/10.1039/C3LC51124C
Article type
Tutorial Review
Submitted
04 Oct 2013
Accepted
24 Jan 2014
First published
24 Jan 2014

Lab Chip, 2014,14, 1496-1514

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Microfluidic platforms for biomarker analysis

S. Nahavandi, S. Baratchi, R. Soffe, S. Tang, S. Nahavandi, A. Mitchell and K. Khoshmanesh, Lab Chip, 2014, 14, 1496 DOI: 10.1039/C3LC51124C

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