Issue 29, 2011

Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification

Abstract

We report here an ultrasensitive DNA detection approach which combines Au NPs enhanced electrochemiluminescence (ECL) of the CdS nanocrystal (NC) film with isothermal circular amplification reaction of polymerase and nicking endonuclease (NEase). By the double-signal amplification, this approach could sensitively respond down to 5 aM DNA.

Graphical abstract: Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2011
Accepted
07 Jun 2011
First published
21 Jun 2011

Chem. Commun., 2011,47, 8358-8360

Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification

H. Zhou, J. Liu, J. Xu and H. Chen, Chem. Commun., 2011, 47, 8358 DOI: 10.1039/C1CC12413G

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