A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

Young-Kwan Kim; Li-Sheng Wang; Ryan Landis; Chang Soo Kim; Richard W. Vachet; Vincent M. Rotello

doi:10.1039/C7NR02949G

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A layer-by-layer assembled MoS₂ thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules†

Young-Kwan Kim,

^ab Li-Sheng Wang,^a Ryan Landis,^a Chang Soo Kim,^a Richard W. Vachet*^a and Vincent M. Rotello

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA
E-mail: rotello@chem.umass.edu

^b Carbon Composite Materials Research Center, Korea Institute of Science and Technology, San 101, Eunha-ri, Bongdong-eup, Wanju-gun, Jeollabuk-do, Korea

Abstract

A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS₂ nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS₂ films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS₂ nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

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Article information

DOI: https://doi.org/10.1039/C7NR02949G
Article type: Paper
Submitted: 25 Apr 2017
Accepted: 26 Jun 2017
First published: 28 Jun 2017

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Nanoscale, 2017,9, 10854-10860

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A layer-by-layer assembled MoS₂ thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

Y. Kim, L. Wang, R. Landis, C. S. Kim, R. W. Vachet and V. M. Rotello, Nanoscale, 2017, 9, 10854 DOI: 10.1039/C7NR02949G

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