Issue 103, 2016
From the journal:

RSC Advances

A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations†

Cynthia M. Archambaulta  and  Nicholas E. Leadbeater ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, USA
E-mail: nicholas.leadbeater@uconn.edu

Abstract

An approach is reported for monitoring continuous-flow reactions by means of a low-field benchtop NMR spectrometer. The spectrometer is interfaced with a mesofluidic reactor and used as a tool for optimising four organic transformations, namely an acid-catalysed esterification, a Knoevenagel condensation, a Diels–Alder reaction, and an alkylation. Reactions need to be performed either solvent-free or at relatively high concentration in order to monitor them effectively using the NMR spectrometer, but this allows for the leveraging of one of the key advantages of flow processing, namely process intensification.

Graphical abstract: A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations

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Article information

DOI
https://doi.org/10.1039/C6RA19662D
Article type
Paper
Submitted
03 Aug 2016
Accepted
12 Oct 2016
First published
13 Oct 2016

RSC Adv., 2016,6, 101171-101177

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A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations

C. M. Archambault and N. E. Leadbeater, RSC Adv., 2016, 6, 101171 DOI: 10.1039/C6RA19662D

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