Issue 115, 2016, Issue in Progress
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RSC Advances

Magnetic iron nanoparticles for in vivo targeted delivery and as biocompatible contrast agents

C. S. Tiwary,†*a   Rajeev J. Mudakavi,†ac   Sharan Kishore,†b   Sanjay Kashyap,a   Rajasegaran Elumalai,a   Dipshikha Chakravortty,*bc   Ashok M. Raichurac  and  K. Chattopadhyay*a  

* Corresponding authors

a Department of Materials Engineering, Indian Institute of Science, Bangalore-560012, Karnataka, India
E-mail: cst.iisc@gmail.com, kamanio@materials.iisc.ernet.in

b Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

c Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India

Abstract

Iron nanoparticles (NPs) of size less than 20 nm were synthesized using an in-house developed cryomill. These NPs exhibit values of saturation magnetisation (∼180 emu g−1) close to that of pure iron. The particles were found to be nontoxic at concentrations required for MRI imaging as indicated by MTT assay. In vivo studies demonstrated the suitability of using these particles as contrast agents for MRI. The iron NPs were bio-capped with TRITC–dextran and injected into mice to study the transport behavior of the NPs under the influence of an external magnetic field. The iron NPs showed enhanced aggregation and contrast when a bar magnet was placed on the mice as observed by whole body fluorescence imaging.

Graphical abstract: Magnetic iron nanoparticles for in vivo targeted delivery and as biocompatible contrast agents

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Article information

DOI
https://doi.org/10.1039/C6RA14817D
Article type
Communication
Submitted
07 Jun 2016
Accepted
01 Dec 2016
First published
02 Dec 2016

RSC Adv., 2016,6, 114344-114352

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Magnetic iron nanoparticles for in vivo targeted delivery and as biocompatible contrast agents

C. S. Tiwary, R. J. Mudakavi, S. Kishore, S. Kashyap, R. Elumalai, D. Chakravortty, Ashok M. Raichur and K. Chattopadhyay, RSC Adv., 2016, 6, 114344 DOI: 10.1039/C6RA14817D

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