Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

Nicolas P. E. Barry; Anaïs Pitto-Barry; Isolda Romero-Canelón; Johanna Tran; Joan J. Soldevila-Barreda; Ian Hands-Portman; Corinne J. Smith; Nigel Kirby; Andrew P. Dove; Rachel K. O'Reilly; Peter J. Sadler

doi:10.1039/C4FD00098F

Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

Nicolas P. E. Barry,*^a Anaïs Pitto-Barry,^a Isolda Romero-Canelón,^a Johanna Tran,^a Joan J. Soldevila-Barreda,^a Ian Hands-Portman,^b Corinne J. Smith,^b Nigel Kirby,^c Andrew P. Dove,^a Rachel K. O'Reilly^a and Peter J. Sadler*^a

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^a Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
E-mail: N.Barry@warwick.ac.uk, P.J.Sadler@warwick.ac.uk

^b School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK

^c Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168, Australia

Abstract

We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core–shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC₅₀ 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC₅₀ 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells.

This article is part of the themed collection: Physical Chemistry of Functionalised Biomedical Nanoparticles

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Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

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