Issue 27, 2011

Anticancer activity of tetracationic arene ruthenium metalla-cycles

Abstract

A series of cationic metalla-cycles of the general formulae [(η6-p-cym)4Ru4(OOOO)2(NN)2]4+ and [(η6-p-cym)4Ru4(NONO)2(NN)2]4+ has been prepared from the dinuclear arene ruthenium precursors [(η6-p-cym)2Ru2(OOOO)2Cl2] (OOOO = oxalato, 1,4-benzoquinonato-2,5-diolato, 1,4-naphtoquinonato-5,8-diolato, 9,10-anthraquinonato-1,4-diolato, 5,12-tetraquinonato-6,11-diolato) and [(η6-p-cym)2Ru2(NONO)2Cl2] (NONO = oxamido, oxonico) by reaction with two different bidentate linkers (NN = 1,2-bis(4-pyridyl)ethylene, 1,2-bis(4-pyridyl)ethane) in the presence of silver triflate. All complexes were isolated as triflate salts and characterised by NMR, infrared, UV-visible, mass spectrometry and by elemental analysis. The cytotoxicities of the tetranuclear ruthenium complexes have been established using ovarian A2780 and A2780cisR cancer cell lines. All complexes exhibit moderate to excellent activity on both the cisplatin resistant and cisplatin sensitive cells, thus suggesting a mode of action different from cisplatin.

Graphical abstract: Anticancer activity of tetracationic arene ruthenium metalla-cycles

Article information

Article type
Paper
Submitted
23 Mar 2011
Accepted
21 Apr 2011
First published
09 Jun 2011

Dalton Trans., 2011,40, 7172-7180

Anticancer activity of tetracationic arene ruthenium metalla-cycles

N. P. E. Barry, F. Edafe and B. Therrien, Dalton Trans., 2011, 40, 7172 DOI: 10.1039/C1DT10489F

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