The predictable transition-metal-catalysed cyclotrimerization of three different unsaturated substrates in a controlled selective manner is a challenge for synthetic chemists. Now, a highly selective chiral rhodium-catalysed reaction provides selective access to a range of six-membered carbocyclic rings.
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Pla-Quintana, A., Roglans, A. Cyclotrimerization takes orders from rhodium. Nat. Synth 1, 337–338 (2022). https://doi.org/10.1038/s44160-022-00059-8
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DOI: https://doi.org/10.1038/s44160-022-00059-8