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Towards a hit for every target

Abstract

Technological advances coupled with novel collaborative strategies for compound sourcing and management are poised to transform the utility of high-throughput screening.

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References

  1. Macarron, R. et al. Impact of high throughput screening in biomedical research. Nat. Rev. Drug. Discov. 10, 188–195 (2011).

    Article  CAS  Google Scholar 

  2. Cook, D. et al. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework. Nat. Rev. Drug Discov. 13, 419–431 (2014).

    Article  CAS  Google Scholar 

  3. Bakken, G. A. et al. Shaping a screening file for maximal lead discovery efficiency and effectiveness: elimination of molecular redundancy. J. Chem. Inf. Model. 52, 2937–2949 (2012).

    Article  CAS  Google Scholar 

  4. Simpson, P. B. & Reichman, M. Opening the lead generation toolbox. Nat. Rev. Drug Discov. 13, 3–4 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Steve Rees.

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S.R, K.B. and G.P. are employees of AstraZeneca.

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Rees, S., Gribbon, P., Birmingham, K. et al. Towards a hit for every target. Nat Rev Drug Discov 15, 1–2 (2016). https://doi.org/10.1038/nrd.2015.19

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