Trends in Cancer
SpotlightIntrinsic versus Extrinsic Cancer Risks: The Debate Continues
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Cited by (17)
Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis
2017, Current Opinion in ToxicologyCitation Excerpt :Furthermore, there is very little data on potential association of xenobiotic exposure with non-genotoxic carcinogenesis in humans due to the likely latency, very low incidence, and difficulty of deconvoluting environmental versus intrinsic factors for malignancy development. Some insight may be gained from somatic mutational signatures of human tumours that are associated with known mutagenic exposures [11] but there will inevitably be overlap between intrinsic and extrinsic mechanisms [12]. Despite these challenges, there is a need for rigorous cancer risk assessment of xenobiotics to which humans are exposed including treatment with novel therapeutics [13] and occupational or environmental exposure to chemicals [3].
Can chance cause cancer? A causal consideration
2017, European Journal of CancerDerisking Drug-Induced Carcinogenicity for Novel Therapeutics
2016, Trends in CancerCitation Excerpt :The relative importance of environmental versus intrinsic factors in malignancy development has been intensely debated [1–3], but the potential influence of drug exposure has not been extensively explored.
Evolutionary Ecology of Organs: A Missing Link in Cancer Development?
2016, Trends in CancerCitation Excerpt :Organs that are large or paired, and thus can maintain function even when a relatively large tumor is present, will be less subject to anticancer selection forces. Although specific cancer-suppressing mechanisms can vary, in general they result in reduced vulnerability to tumor formation and/or metastatic invasion by mutant clones arising among cell populations under physiological conditions or following perturbations of the tissue adaptive landscape by infection, trauma, or toxins [6,7]. In complex multicellular organisms, cells combine to form tissues, then organs, and, ultimately, arrange in organ systems (see Glossary).
On intrinsic susceptibility of healthy organs to primary cancer or metastasis
2023, Research Square
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All authors have equally contributed to this work