Elsevier

Tetrahedron Letters

Volume 45, Issue 15, 5 April 2004, Pages 3117-3121
Tetrahedron Letters

Pyridine-based receptors with high affinity for carbohydrates. Influence of the degree of steric hindrance at pyridine nitrogen on the binding mode

https://doi.org/10.1016/j.tetlet.2004.02.087Get rights and content

Abstract

Remarkable changes in the binding affinity and selectivity of pyridine-based receptors toward monosaccharides have been observed when the degree of steric hindrance at pyridine nitrogen atom decreases.

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Acknowledgments

This work was supported by the Deutsche Forschungs-gemeinschaft (SFB 452). We thank Prof. Roland Boese and Dieter Bläser for performing the X-ray measurements, and Prof. Craig Wilcox for giving access to the hostest program.

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