Encapsulation of hydrophobic pyrenylcycloplatinate complexes within a water-soluble arene ruthenium metallacage
Graphical abstract
Two hydrophobic pyrenyl-containing cycloplatinate complexes have been encapsulated in a hexacationic water-soluble metalla-cage. The cytotoxicities of the complex-in-a-complex systems have been established and it shows IC50 values in the lower micromolar range (IC50 ≈ 1 μM). These values suggest an efficient delivery of the hydrophobic Pt-complexes by the water-soluble arene ruthenium metalla-cage.
Highlights
► Preparation of hexacationic water-soluble ruthenium metalla-cage. ► Encapsulation of pyrenyl-containing cycloplatinate complex in the cavity of metalla-cage. ► Enhancement of cytotoxicity for the complex-in-a-complex systems. ► Higher activity than cisplatin.
Section snippets
Acknowledgments
A generous loan of ruthenium chloride hydrate from the Johnson Matthey Technology Centre is gratefully acknowledged.
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