Genetic variability of 16 Y-chromosome STRs in a sample from Equatorial Guinea (Central Africa)

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Abstract

Nine Y-STR loci from the “minimal haplotype” included in Y-STR Haplotype Reference Databases (YHRD) together with eight additional Y-STRs (DYS437, DYS438, DYS439, DYS460, DYS461, GATA C4, GATA H4 and GATA A10) were analyzed in a sample of 101 males from Equatorial Guinea living in Madrid. Haplotype and allelic frequencies were calculated and genetic diversities were estimated for each genetic system as well as for the whole haplotype. An unexpected high frequency (6%) of intermediate alleles (13.2 and 14.2) was found in DYS385. For DYS19, two alleles were found in one sample. Another sample failed to amplify with DYS393 primers using either PowerPlex® Y System (Promega Corporation) or the Y-PLEX™ 12 (Reliagene, New Orleans, LA) commercial kits. Comparison between Equatorial Guinea and another African population (Mozambique; South East Coast) revealed a significant pairwise Φst value between them (Φst = 0.03309; P = 0.00000).

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Acknowledgements

This work was partially supported by Fundação para a Ciência e a Tecnologia (POCTI, Programa Operacional Ciência, Tecnologia e Inovação).

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    Citation Excerpt :

    Haplotype diversities were calculated according to Nei [6,7] using Arlequin v3.0 software [6]. Previously published haplotypes and frequencies data from several populations were compiled, which comprised South American (Toba, Argentina [8]; El Beni, Bolivia [9]; Rio de Janeiro, Brazil [10]; Rio Grande do Sul, Brazil [11]; Mestizo, Ecuador [12]; and Kichwa, Ecuador [12]), North American (African descendent; European descendent; Hispanic descendent) [13], African (Algeria [14]; Equatorial Guinea [15]; Ovambo, Namibia [16]), Asian (Japan [17]; Korea [18]; Chinese Tibetan [19]; Chaoshan, China [20]), and European (Spain [21]; Portugal [22]; Italy [23]; Croatia [24]; Serbia [25]; and Austria [26]). To study the ancestry relationships, six markers (DYS385a/b, DYS439, DYS456, DYS458 and DYS635) with the highest mutation rates were eliminated [27].

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