Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD)
Graphical abstract
X-ray co-structure of compound 26.
Section snippets
Acknowledgments
The authors are grateful to Dr. Nelson Huang and Ms. Ning Pan for LC-MS measurements, Drs. Walter Massefski and Vasilios Marathias for the contribution of NMR analysis, Drs. John Kubera and Franklin Schlerman for the lung inflammation experiments and Drs. Iain McFadyen and Diane Joseph-McCarthy for molecular modeling help.
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