A stereochemical switch in the aDrs model system, a candidate for a functional amyloid
Under a Creative Commons license
open access
Highlights
► Residue 2 in frog skin peptide aDrs can be enzymatically converted to a d-amino acid. ► The d-amino acid does not affect the kinetic parameters of aggregation. ► The diastereomers assemble to amyloids with different superstructural architectures. ► pH-triggered, melting of the amyloid is markedly altered by the d-amino acid.
Keywords
d-Amino acid
Bioactive peptide
Self-assembly
Functional amyloid
Posttranslational modification
Amphibian skin
Cited by (0)
- 1
These authors contributed equally to this work.
Copyright © 2012 Elsevier Inc.