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The keto diet and the gut: cause for concern?

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  • Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects

    2022, Neuroscience and Biobehavioral Reviews
    Citation Excerpt :

    Collectively, a KD or KBs could alleviate cognitive impairment in clinical trials. However, 30–50% of individuals who follow KD have side effects such as nausea, vomiting, constipation, and lower appetite, and KD may aggravate the risk of intestinal disease (Tuck & Staudacher, 2019). Notably, the biggest risk of KD is that it eliminates large amounts of carbohydrates, including some abundant unrefined carbohydrates (beans, whole grains, and fruits), which may lead to chronic ketosis (Joshi et al., 2019).

  • Microbiota and body weight control: Weight watchers within?

    2022, Molecular Metabolism
    Citation Excerpt :

    Thus, the use of KD should be carefully regulated and monitored based on the specific medical condition and patient response. For example, concerns in the use of KD have been raised particularly for people with GI disorders or at risk of nutritional deficiency [329,330]. In addition, it was recently shown that KD aggravates cognitive impairment in mice that underwent intermittent hypoxia, by influencing the gut microbiota and by increasing intestinal IFNg-producing Th1 cells [331].

  • Dietary patterns affect Parkinson's disease via the microbiota-gut-brain axis

    2021, Trends in Food Science and Technology
    Citation Excerpt :

    Notably, a recent study found that a long-term Ketogenic diet leads to obesity and impairs metabolic health in mice (Goldberg et al., 2020). Additionally, 30–50% of those who follow the Ketogenic diet suffered from side effects, including nausea, vomiting, constipation, reduced appetite, and the risk of intestinal disease (Tuck & Staudacher, 2019). Further studies are required to investigate whether the Ketogenic diet only improves PD symptoms in the short term or whether the effects are longer lasting.

  • Ketone Body Metabolism and Renal Diseases

    2023, Journal of Sichuan University (Medical Science)
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