Elsevier

Tetrahedron

Volume 50, Issue 39, 1994, Pages 11369-11378
Tetrahedron

Potent new cell adhesion inhibitory compounds from the root of Trichilia rubra

https://doi.org/10.1016/S0040-4020(01)89279-6Get rights and content

Abstract

A series of seco-limonoids, with uncommon hemi ortho ester A-rings, was isolated from the root of Trichilia rubra. Their structures were determined by extensive spectroscopic studies. The five new and two previously known compounds were all found to be potent inhibitors of LFA-1:ICAM-1 mediated cell adhesion.

Five new and two known seco-limonoids were isolated from Trichilia rubra. Their structures were elucidated by spectroscopic studies. All seven compounds were found to be potent inhibitors of β2-integrin mediated cell adhesion.

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