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Marine anticancer drugs and their relevant targets: a treasure from the ocean

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Abstract

Marine organisms comprising animals and plants are wealthiest sources of bioactive compounds possessing various pharmacological properties specifically: free radical scavenging, antitumor, antimicrobial, analgesic, neuroprotective and immunomodulatory. Marine drugs provide an alternative source to meet the demand of effective, safe and low-cost drugs that are rising with the continuously growing world population. Cancer is one of the leading reasons of mortality in western nations in contrast to communicable diseases of developing nations. In spite of outstanding developments in cancer therapy in past three decades, there is still an insistent necessity for innovative drugs in the area of cancer biology, especially in the unexplored area of marine anticancer compounds. However, recent technological innovations in structure revelation, synthetic creation of new compounds and biological assays have made possible the isolation and clinical assessment of innumerable unique anticancer compounds from marine environment. This review provides an insight into the anticancer research so far conducted in the area of the marine natural products/synthetic derivatives, their possible molecular targets and the current challenges in the drug development.

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Acknowledgments

Authors are very thankful to all the authors whose work has been cited in this paper. Figures of the compounds has been drawn using ChemDraw software. 

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Authors and Affiliations

  1. Department of Biochemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal, Uttarakhand, 246174, India

    Manisha Nigam

  2. Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin University, Pigdons Road, Waurn Ponds, Victoria, 3216, Australia

    Hafiz Ansar Rasul Suleria

  3. UQ Diamantina Institute, Translational Research Institute, Faculty of Medicine, The University of Queensland, 37 Kent Street Woolloongabba, Brisbane, QLD, 4102, Australia

    Hafiz Ansar Rasul Suleria

  4. Department of Food, Nutrition, Dietetics and Health, Kansas State University, Manhattan, KS, 66506, USA

    Hafiz Ansar Rasul Suleria

  5. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mohammad Hosein Farzaei

  6. Department of Pharmaceutical Chemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal, Uttarakhand, 246174, India

    Abhay Prakash Mishra

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  1. Manisha Nigam
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Nigam, M., Suleria, H.A.R., Farzaei, M.H. et al. Marine anticancer drugs and their relevant targets: a treasure from the ocean. DARU J Pharm Sci 27, 491–515 (2019). https://doi.org/10.1007/s40199-019-00273-4

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