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Zein-based solid dispersion for potential application in targeted delivery

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Abstract

The study aims to design and evaluate the ability of zein in solid dispersion (SD) system to enhance drug dissolution rate for a further application of colonic delivery of poorly water-soluble drug. The SD samples were prepared by solvent method and the investigation of drug release was performed at pH 7.4. The wettability, molecular interactions and drug’s crystal behaviours of SDs were studied by contact angle measurement, Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (PXRD), respectively. Zein-based SDs showed its potential in enhancing the rate of drug release. The PXRD results pointed out a rearrangement of drug’s crystalline structure in some SD samples through the appearance of new peaks on PXRD diffractogram, while a formation of a hydrogen bond between prednisolone (PRL) and zein was also confirmed by FTIR spectra. It was evident that a strong relationship between the amount of zein and the dissolution rate of PRL in SD system attributed to zein hydrophobicity, recrystallization and molecular interaction which were factors inducing the enhanced drug release rate. In conclusion, zein is a potential carrier for controlled release SD systems, especially further application for poorly water-soluble drugs in colonic delivery like PRL due to the resistance of zein at low pH environment.

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Abbreviations

BCS:

Biopharmaceutics classification system

FTIR:

Fourier transform infrared spectroscopy

HPLC:

High performance liquid chromatography

PRL:

Prednisolone

PXRD:

Powder X-ray diffraction

SD:

Solid dispersion

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Acknowledgements

This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant Number 106-YS.05-2015.02.

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Authors and Affiliations

  1. Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Vietnam

    Minh Ngoc-Uyen Nguyen, Toi Van Vo & Thao Truong-Dinh Tran

  2. School of Medicine, Deakin University, Waurn Ponds, VIC, Australia

    Phuong Ha-Lien Tran

Authors
  1. Minh Ngoc-Uyen Nguyen
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  2. Toi Van Vo
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  3. Phuong Ha-Lien Tran
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  4. Thao Truong-Dinh Tran
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Correspondence to Phuong Ha-Lien Tran or Thao Truong-Dinh Tran.

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Nguyen, M.NU., Van Vo, T., Tran, P.HL. et al. Zein-based solid dispersion for potential application in targeted delivery. Journal of Pharmaceutical Investigation 47, 357–364 (2017). https://doi.org/10.1007/s40005-017-0314-z

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  • DOI: https://doi.org/10.1007/s40005-017-0314-z

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