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Association Study between Auditory P3a/P3b Event-Related Potentials and Thought Disorder in Schizophrenia

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Abstract

Thought disorder is considered as one of the core features of schizophrenia and several research groups previously reported an association between P300 (P3b) amplitude and thought disorder in schizophrenia. However, previous studies have not evaluated two P300 subcomponents (P3a and P3b) to investigate whether the relationship with thought disorder was specific to P3b. In this study, we measured P3b and thought disorder of 60 patients with schizophrenia. We also measured P3a of 36 patients out of this sample. We replicated correlation between P3b amplitude and thought disorder and extended this finding by observing that this correlation was not present for the P3a subcomponent. These results suggest that specific electrophysiological abnormalities associated with context updating may underlie thought disorder in schizophrenia.

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References

  • Araki, T., Kasai, K., Kirihara, K., Yamasue, H., Kato, N., Kudo, N., et al. (2006). Auditory P300 latency prolongation with age in schizophrenia: Gender and subcomponent effects. Schizophrenia Research, 88(1–3), 217–221. doi:10.1016/j.schres.2006.06.031.

    Article  PubMed  Google Scholar 

  • Bledowski, C., Prvulovic, D., Hoechstetter, K., Scherg, M., Wibral, M., Goebel, R., et al. (2004). Localizing P300 generators in visual target and distractor processing: A combined event-related potential and functional magnetic resonance imaging study. The Journal of Neuroscience, 24(42), 9353–9360. doi:10.1523/JNEUROSCI.1897-04.2004.

    Article  PubMed  CAS  Google Scholar 

  • First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1996). Structured clinical interview for DSM-IV Axis I disorders Version 2. New York, U.S.A: Biometrics Research Department, New York State Psychiatric Institute. (Japanese version: Kitamura, T., Okano, T. (2003). Tokyo, Japan: Nihon Hyoron-sha publishers).

    Google Scholar 

  • Ford, J. M., Mathalon, D. H., Marsh, L., Faustman, W. O., Harris, D., Hoff, A. L., et al. (1999). P300 amplitude is related to clinical state in severely and moderately ill schizophrenics. Biological Psychiatry, 46(1), 94–101. doi:10.1016/S0006-3223(98)00290-X.

    Article  PubMed  CAS  Google Scholar 

  • Gorham, D. R. (1956). A proverbs test for clinical and experimental use. Psychological Reports, 1, 1–12.

    Article  Google Scholar 

  • Hata, A., Iwanami, A., Nakagome, K., & Niwa, S. (2002). Scoring manual for comprehension index of positive thought disorder. In: Thought Disorder: Assessment and background (in Japanese). Shinko-Igaku Publishers, Tokyo.

  • Higashima, M., Urata, K., Kawasaki, Y., Maeda, Y., Sakai, N., Mizukoshi, C., et al. (1998). P300 and the thought disorder factor extracted by factor-analytic procedures in schizophrenia. Biological Psychiatry, 44(2), 115–120. doi:10.1016/S0006-3223(97)00359-4.

    Article  PubMed  CAS  Google Scholar 

  • Iwanami, A., Okajima, Y., Kuwakado, D., Isono, H., Kasai, K., Hata, A., et al. (2000). Event-related potentials and thought disorder in schizophrenia. Schizophrenia Research, 42(3), 187–191. doi:10.1016/S0920-9964(99)00132-2.

    Article  PubMed  CAS  Google Scholar 

  • Johnston, M. H., & Holzman, P. S. (1979). Assessing schizophrenic thinking: A clinical and research instrument for measuring thought disorder. San Francisco: Jossey-Bass.

    Google Scholar 

  • Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13(2), 261–276.

    PubMed  CAS  Google Scholar 

  • Kircher, T. T., Liddle, P. F., Brammer, M. J., Williams, S. C. R., Murray, R. M., & McGuire, P. K. (2001). Neural correlates of formal thought disorder in schizophrenia: Preliminary findings from a functional magnetic resonance imaging study. Archives of General Psychiatry, 58(8), 769–774. doi:10.1001/archpsyc.58.8.769.

    Article  PubMed  CAS  Google Scholar 

  • Kirihara, K., Araki, T., Kasai, K., Maeda, K., Hata, A., Uetsuki, M., et al. (2005). Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia. Schizophrenia Research, 80(2–3), 197–201. doi:10.1016/j.schres.2005.08.003.

    Article  PubMed  Google Scholar 

  • Knight, R. T. (1984). Decreased response to novel stimuli after prefrontal lesions in man. Electroencephalography and Clinical Neurophysiology, 59(1), 9–20. doi:10.1016/0168-5597(84)90016-9.

    Article  PubMed  CAS  Google Scholar 

  • Knight, R. T., Scabini, D., Woods, D., & Clayworth, C. (1989). Contributions of temporal parietal junction to the human auditory P3. Brain Research, 502(1), 109–116. doi:10.1016/0006-8993(89)90466-6.

    Article  PubMed  CAS  Google Scholar 

  • Lew, G. S., & Polich, J. (1993). P300, habituation, and response mode. Physiology & Behavior, 53(1), 111–117. doi:10.1016/0031-9384(93)90018-B.

    Article  CAS  Google Scholar 

  • Liddle, P. F. (1987). The symptoms of chronic schizophrenia: a re-examination of the positive-negative dichotomy. The British Journal of Psychiatry, 151(2), 145–151. doi:10.1192/bjp. 151.2.145.

    Article  PubMed  CAS  Google Scholar 

  • Marengo, J. T., & Harrow, M. (1985). Thought disorder: a function of schizophrenia, mania or psychosis? The Journal of Nervous and Mental Disease, 173(1), 35–41. doi:10.1097/00005053-198501000-00006.

    Article  PubMed  CAS  Google Scholar 

  • Marengo, J. T., & Harrow, M. (1987). Schizophrenic thought disorder at follow-up. A persistent or episodic course? Archives of General Psychiatry, 44(7), 651–659.

    PubMed  CAS  Google Scholar 

  • Marengo, J. T., Harrow, M., Latin Kettering, L., & Wilson, A. (1986). Evaluating bizarre-idiosyncratic thinking: a comprehensive index of positive thought disorder. Schizophrenia Bulletin, 12(3), 497–511.

    PubMed  CAS  Google Scholar 

  • Mathalon, D. H., Ford, J. M., & Pfefferbaum, A. (2000). Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biological Psychiatry, 47(5), 434–449. doi:10.1016/S0006-3223(99)00277-2.

    Article  PubMed  CAS  Google Scholar 

  • McCarley, R. W., Faux, S. F., Shenton, M. E., Nestor, P. G., & Adams, J. (1991). Event-related potentials in schizophrenia–Their biological and clinical correlates and a new model of schizophrenic pathophysiology. Schizophrenia Research, 4(2), 209–231. doi:10.1016/0920-9964(91)90034-O.

    Article  PubMed  CAS  Google Scholar 

  • McCarley, R. W., Shenton, M. E., O'Donnell, B. F., Faux, S. F., Kikinis, R., Nestor, P. G., et al. (1993). Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Archives of General Psychiatry, 50(3), 190–197.

    PubMed  CAS  Google Scholar 

  • Nieuwenhuis, S., Aston-Jones, G., & Cohen, J. D. (2005). Decision making, the P3, and the locus coeruleus-norepinephrine system. Psychological Bulletin, 131(4), 510–532. doi:10.1037/0033-2909.131.4.510.

    Article  PubMed  Google Scholar 

  • Oldfield, R. C. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9(1), 97–113. doi:10.1016/0028-3932(71)90067-4.

    Article  PubMed  CAS  Google Scholar 

  • Poceta, S. J., Houser, M., & Polich, J. (2006). Event-related potentials in restless legs syndrome and Parkinson’s disease. Sleep, 28, A274. abstract.

    Google Scholar 

  • Polich, J. (2007). Updating P300: an integrative theory of P3a and P3b. Clinical Neurophysiology, 118(10), 2128–2148. doi:10.1016/j.clinph.2007.04.019.

    Article  PubMed  Google Scholar 

  • Polich, J., & Criado, J. R. (2006). Neuropsychology and neuropharmacology of P3a and P3b. International Journal of Neurophysiology, 69(2), 172–185.

    Google Scholar 

  • Schall, U., Catts, S. V., Karayanidis, F., & Ward, P. B. (1999). Auditory event-related potential indices of fronto-temporal information processing in schizophrenia syndromes: Valid outcome prediction of clozapine therapy in a three-year follow-up. The International Journal of Neuropsychopharmacology, 2(2), 83–93. doi:10.1017/S1461145799001418.

    Article  PubMed  Google Scholar 

  • Shenton, M. E., Kikinis, F. A., Jolesz, S. D., Pollak, S. D., LeMay, M., Wible, C. G., et al. (1992). Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative magnetic resonance imaging study. The New England Journal of Medicine, 327(9), 604–612.

    Article  PubMed  CAS  Google Scholar 

  • Squires, N. K., Squires, K. C., Hillyard, S. A. (1975). Two-varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalography and Clinical Neurophysiology, 38(4), 387–401.

    Article  CAS  Google Scholar 

  • Subotnik, K. L., Nuechterlein, K. H., Green, M. F., Horan, W. P., Nienow, T. M., Ventura, J., et al. (2006). Neurocognitive and social correlates of formal thought disorder in schizophrenia patients. Schizophrenia Research, 85(1–3), 84–95. doi:10.1016/j.schres.2006.03.007.

    Article  PubMed  Google Scholar 

  • Turetsky, B. I., Calkins, M. E., Light, G. A., Olincy, A., Radant, A. D., & Swerdlow, N. R. (2007). Neurophysiological endophenotypes of schizophrenia: The viability of selected candidate measures. Schizophrenia Bulletin, 33(1), 69–94. doi:10.1093/schbul/sbl060.

    Article  PubMed  Google Scholar 

  • Verleger, R., Heide, W., Butt, C., & Kompf, D. (1994). Reduction of P3b in patients with temporo-parietal lesions. Brain Research. Cognitive Brain Research, 2(2), 103–116. doi:10.1016/0926-6410(94)90007-8.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported in part by grants-in-aid for scientific research (No. 16790675 and 17025015 to KK) from Japan Society for the Promotion of Science and the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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Authors and Affiliations

  1. Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo, 113-8655, Japan

    Kenji Kirihara, Tsuyoshi Araki, Miki Uetsuki, Hidenori Yamasue & Kiyoto Kasai

  2. Fukushima Prefectural Mental Health and Welfare Centre, 8-30 Oyamacho, Fukushimashi, Fukushima, 960-8012, Japan

    Akinobu Hata

  3. Department of Psychology, Monash University, Clayton 3168, Monash, Victoria, Australia

    Mark A. Rogers

  4. Department of Psychiatry, Saitama Medical School, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan

    Akira Iwanami

Authors
  1. Kenji Kirihara
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  2. Tsuyoshi Araki
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  3. Miki Uetsuki
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  4. Hidenori Yamasue
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  5. Akinobu Hata
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  6. Mark A. Rogers
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  7. Akira Iwanami
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  8. Kiyoto Kasai
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Correspondence to Kenji Kirihara or Kiyoto Kasai.

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Kirihara, K., Araki, T., Uetsuki, M. et al. Association Study between Auditory P3a/P3b Event-Related Potentials and Thought Disorder in Schizophrenia. Brain Imaging and Behavior 3, 277–283 (2009). https://doi.org/10.1007/s11682-009-9069-0

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  • DOI: https://doi.org/10.1007/s11682-009-9069-0

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