Abstract
A number of randomised controlled trials have indicated that multivitamin/mineral supplementation for a period of 4 weeks or greater can enhance mood and cognition. To date, no studies have investigated whether a single multivitamin dose can benefit mental function in older adults. This study investigated the acute effects of a single multivitamin and mineral and herbal (MVMH) supplement versus placebo on self ratings of mood and the performance of an effortful computerised cognitive battery in a sample of 76 healthy women aged 50–75 years. Mood was assessed using the depression anxiety stress scale (DASS), state trait anxiety inventory–state anxiety scale and visual analogue scales (VAS). Mood was rated at 1 h post supplementation and again after the competition of the cognitive assessments at 2 h post supplementation. It was demonstrated that the MVMH supplement improved overall DASS mood ratings; however, the most prominent effects appeared to be a reduction in ratings of perceived mental stress. These findings were confirmed using visual analogue scales, with these measures also demonstrating MVMH-related increased ratings of calmness. There were no benefits of the MVMH to mood ratings of depression and performance was not enhanced on the cognitive battery. Supplementation with a single multivitamin, mineral and herbal supplement reduces stress several hours after intake in healthy older people.
Similar content being viewed by others
References
Alpert JE, Mischoulon D, Nierenberg AA, Fava M (2000) Nutrition and depression: focus on folate. Nutrition 16:544–546
Baldewicz TT, Goodkin K, Blaney NT, Shor-Posner G, Kumar M, Wilkie FL, Baum MK, Eisdorfer C (2000) Cobalamin level is related to self-reported and clinically rated mood and to syndromal depression in bereaved HIV-1+ and HIV-1- homosexual men. J Psychosom Res 48:177–185
Benton D (2002) Selenium intake, mood and other aspects of psychological functioning. Nutr Neurosci 5:363–374
Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Psychol 47:211–218
Bottiglieri T (2005) Homocysteine and folate metabolism in depression. Prog Neuropsychopharmacol Biol Psychiatry 29:1103–1112
Brownie S (2006) Why are elderly individuals at risk of nutritional deficiency? Int J Nurs Pract 12:110–118
Carroll D, Ring C, Suter M, Willemsen G (2000) The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology 150:220–225
Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatric Res 12:189–198
Grima NA, Pase MP, Macpherson H, Pipingas A (2012) The effects of multivitamins on cognitive performance: a systematic review and meta-analysis. J Alzheimers Dis 29:561–569
Harris E, Kirk J, Rowsell R, Vitetta L, Sali A, Scholey AB, Pipingas A (2011) The effect of multivitamin supplementation on mood and stress in healthy older men. Hum Psychopharmacol 26:560–567
Harris E, Kirk J, Vitetta L, Macpherson H, Sali A, Pipingas A (2012) Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in a group of older males: a randomised, placebo controlled trial. Hum Psychopharmacol 27:370–377
Haskell CF, Scholey AB, Jackson PA, Elliott JM, Defeyter MA, Greer J, Robertson BC, Buchanan T, Tiplady B, Kennedy DO (2008) Cognitive and mood effects in healthy children during 12 weeks' supplementation with multi-vitamin/minerals. Br J Nutr 100:1086–1096
Haskell CF, Robertson B, Jones E, Forster J, Jones R, Wilde A, Maggini S, Kennedy DO (2010) Effects of a multi-vitamin/mineral supplement on cognitive function and fatigue during extended multi-tasking. Hum Psychopharmacol 25:448–461
Huskisson E, Maggini S, Ruf M (2007) The influence of micronutrients on cognitive function and performance. J Int Med Res 35:1–19
Kaplan BJ, Crawford SG, Field CJ, Simpson JSA (2007) Vitamins, minerals, and mood. Psychol Bull 133:747–760
Kemeny ME (2003) The psychobiology of stress. Curr Dir Psychol Sci 12:124–129
Kennedy DO, Haskell CF, Robertson B, Reay J, Brewster-Maund C, Luedemann J, Maggini S, Ruf M, Zangara A, Scholey AB (2008) Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guarana (Paullinia cupana). Appetite 50:506–513
Kennedy DO, Veasey R, Watson A, Dodd F, Jones E, Maggini S, Haskell CF (2010) Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology 211:1–14
Levenson CW (2006) Zinc: the new antidepressant? Nutr Rev 64:39–42
Long SJ, Benton D (2013) Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis. Psychosomatic Med 75:144–153
Lovibond SH LP (1995) Manual for the Depression Anxiety Stress Scales. In: Foundation P (ed), Sydney, Australia
Lovibond SH, Lovibond PF (1995) Manual for the Depression Anxiety Stress Scales. Psychology Foundation, Sydney, Australia
Macpherson H, Ellis KA, Sali A, Pipingas A (2012) Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement—a randomised controlled trial. Psychopharmacology 220:351–365
Maki KC, Ndife LI, Kelley KM, Lawless AL, Brooks JR, Wright SB, Shields JM, Dicklin MR (2012) Absorption of folic acid from a softgel capsule compared to a standard tablet. J Acad Nutr Diet 112:1062–1067
Malouf R, Grimley Evans J, Areosa Sastre A (2003) Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database of Systematic Reviews
Nelson HE, Willison J (1991) National Adult Reading Test (NART) test manual, Second Edition edn
Pipingas A, Camfield DA, Stough C, Cox KH, Fogg E, Tiplady B, Sarris J, White DJ, Sali A, Wetherell MA, Scholey AB (2013) The effects of multivitamin supplementation on mood and general well-being in healthy young adults. A laboratory and at-home mobile phone assessment. Appetite 69:123–136
Pipingas A, Camfield DA, Stough C, Scholey AB, Cox KHM, White D, Sarris J, Sali A, Macpherson H (2014) Effects of multivitamin, mineral and herbal supplement on cognition in younger adults and the contribution of B group vitamins. Hum Psychopharmacol 29:73–82
Schlebusch L, Bosch BA, Polglase G, Kleinschmidt I, Pillay BJ, Cassimjee MH (2000) A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combination on stress. S Afr Med J 90:1216–1223
Scholey A, Harper S, Kennedy DO (2001) Cognitive demand and blood glucose. Physiol Behav 73:585–592
Scholey A, Bauer I, Neale C, Savage K, Camfield D, White D, Maggini S, Pipingas A, Stough C, Hughes M (2013) Acute effects of different multivitamin mineral preparations with and without guaraná on mood, cognitive performance and functional brain activation. Nutrients 5:3589–3604
Speilberger CD, Gorsuch RL, Lushene RE (1969) STAI. Manual for the state-trait anxiety inventory. Consulting Psychologists Press, Palo Alto
Stough C, Scholey A, Lloyd J, Spong J, Myers S, Downey LA (2011) The effect of 90 day administration of a high dose vitamin B-complex on work stress. Hum Psychopharmacol 26:470–476
Summers WK, Martin RL, Cunningham M, Deboynton VL, Marsh GM (2010) Complex antioxidant blend improves memory in community-dwelling seniors. J Alzheimer's Dis 19:429–439
Tolmunen T, Voutilainen S, Hintikka J, Rissanen T, Tanskanen A, Viinamaki H, Kaplan GA, Salonen JT (2003) Dietary folate and depressive symptoms are associated in middle-aged Finnish men. J Nutr 133:3233–3236
White DJ, Camfield DA, Maggini S, Pipingas A, Silberstein R, Stough C, Scholey A (2014) The effect of a single dose of multivitamin and mineral combinations with and without guarana on functional brain activity during a continuous performance task. Nutr Neurosci
Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC (2006) Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatric Psychiatry 14:1032–1040
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Macpherson, H., Rowsell, R., Cox, K.H.M. et al. Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial. AGE 37, 38 (2015). https://doi.org/10.1007/s11357-015-9782-0
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s11357-015-9782-0