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Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method

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Abstract

Purpose

This study is to design a sustained release solid dispersion using swellable polymer by melting method.

Methods

Polyethylene glycol 6000 (PEG 6000) and hydroxypropyl methylcellulose 4000 (HPMC 4000) were used in solid dispersion for not only enhancing drug dissolution rate but also sustaining drug release. HPMC 4000 is a common swellable polymer in matrix sustained release dosage form, but could not be used in preparation of solid dispersion by melting method. However, the current study utilized the swelling capability of HPMC 4000 accompanied by the common carrier PEG 6000 in solid dispersion to accomplish the goal.

Results

While PEG 6000 acted as a releasing stimulant carrier and provided an environment to facilitate the swelling of HPMC 4000, this swellable polymer could act as a rate-controlling agent. This greatly assisted the dissolution enhancement by changing the crystalline structure of drug to more amorphous form and creating a molecular interaction.

Conclusions

These results suggested that this useful technique can be applied in designing a sustained release solid dispersion with many advantages.

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Abbreviations

FTIR:

Fourier transform infrared spectroscopy

HPMC 4000:

Hydroxypropyl methylcellulose 4000

PEG 6000:

Polyethylene glycol 6000

PM:

Physical mixture

PXRD:

Powder X-ray diffraction

SD:

Solid dispersion

SR:

Sustained release

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ACKNOWLEDGMENTS AND DISCLOSURES

This research is supported by Vietnam National University – Ho Chi Minh City. We also thank to International University for their continued, generous and invaluable support to our studies as well as greatly boost the efficiency of our research activities

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    Authors and Affiliations

    1. Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Vietnam

      Tuong Ngoc-Gia Nguyen, Phuong Ha-Lien Tran, Toi Van Vo & Thao Truong-Dinh Tran

    2. School of Medicine, Deakin University, Waurn Ponds, VIC, Australia

      Phuong Ha-Lien Tran & Wei Duan

    3. Institute for Frontier Materials, Deakin University, Waurn Ponds, VIC, Australia

      Thao Truong-Dinh Tran

    Authors
    1. Tuong Ngoc-Gia Nguyen
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    2. Phuong Ha-Lien Tran
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    3. Toi Van Vo
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    4. Wei Duan
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    5. Thao Truong-Dinh Tran
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    Corresponding authors

    Correspondence to Phuong Ha-Lien Tran or Thao Truong-Dinh Tran.

    Additional information

    Tuong Ngoc-Gia Nguyen and Phuong Ha-Lien Tran contributed equally to this work.

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    Nguyen, T.NG., Tran, P.HL., Van Vo, T. et al. Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method. Pharm Res 33, 102–109 (2016). https://doi.org/10.1007/s11095-015-1767-2

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    • DOI: https://doi.org/10.1007/s11095-015-1767-2

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