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Chemical oxidation of silicon oxycarbide ceramics for advanced drug delivery systems

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Abstract

Silicon oxycarbide particles were subjected to chemical oxidation processes to incorporate carbonyl and carboxylic functionalities on their surfaces. These materials were subjected to in vitro tests to determine their adsorption and release capabilities of the antiretroviral drug molecule acyclovir. The spectroscopic characterization revealed the distribution of the functionalities in the different nanophases contained within the silicon oxycarbide structure. This selective distribution in either the carbon or the silicon oxycarbide phase leads to a differential charge availability that in fact is responsible for the adsorption of the drug molecule on the surface of the particles. This adsorption occurs via donor–acceptor interactions with no chemical bonds involved in the drug delivery system.

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Acknowledgements

This work was carried out with the financial support of the Spanish Ministry of Economics and Competitiveness, research project MAT2012-34552. A. Tamayo is indebted to CSIC for her JAE-DOC Grant supported by the program “Junta para la Ampliación de Estudios” and co-financed by the FSE.

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Authors and Affiliations

  1. Ceramics and Glass Institute, CSIC, Kelsen 5, 28049, Madrid, Spain

    Aitana Tamayo, Alejandra Mazo & Juan Rubio

  2. Pharmaceutical Technology Department, Faculty of Pharmacy, Universidad Complutense de Madrid, Plaza Ramón y Cajal s.n, 28007, Madrid, Spain

    Roberto Ruiz-Caro & Maria D. Veiga-Ochoa

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  1. Aitana Tamayo
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  2. Roberto Ruiz-Caro
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  4. Maria D. Veiga-Ochoa
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  5. Juan Rubio
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Correspondence to Aitana Tamayo.

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Tamayo, A., Ruiz-Caro, R., Mazo, A. et al. Chemical oxidation of silicon oxycarbide ceramics for advanced drug delivery systems. J Mater Sci 51, 1382–1391 (2016). https://doi.org/10.1007/s10853-015-9457-3

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