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The role of depression pharmacogenetic decision support tools in shared decision making

  • Psychiatry and Preclinical Psychiatric Studies - Short communication
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Abstract

Patients discontinue antidepressant medications due to lack of knowledge, unrealistic expectations, and/or unacceptable side effects. Shared decision making (SDM) invites patients to play an active role in their treatment and may indirectly improve outcomes through enhanced engagement in care, adherence to treatment, and positive expectancy of medication outcomes. We believe decisional aids, such as pharmacogenetic decision support tools (PDSTs), facilitate SDM in the clinical setting. PDSTs may likewise predict drug tolerance and efficacy, and therefore adherence and effectiveness on an individual-patient level. There are several important ethical considerations to be navigated when integrating PDSTs into clinical practice. The field requires greater empirical research to demonstrate clinical utility, and the mechanisms thereof, as well as exploration of the ethical use of these technologies.

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Acknowledgements

MB is currently supported by a NHMRC Senior Principal Research Fellowship 1059660.

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Authors and Affiliations

  1. IMPACT SRC, School of Medicine, Deakin University, Geelong, VIC, 3216, Australia

    Katarina Arandjelovic, Harris A. Eyre, Ajeet B. Singh & Michael Berk

  2. Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia

    Harris A. Eyre

  3. Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia

    Harris A. Eyre, Michael Berk & Chad Bousman

  4. Innovation Institute, Texas Medical Center, Houston, TX, USA

    Harris A. Eyre

  5. Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA

    Eric Lenze

  6. Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia

    Michael Berk

  7. Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada

    Chad Bousman

Authors
  1. Katarina Arandjelovic
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  2. Harris A. Eyre
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  3. Eric Lenze
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  4. Ajeet B. Singh
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  5. Michael Berk
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  6. Chad Bousman
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Correspondence to Katarina Arandjelovic.

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Arandjelovic, K., Eyre, H.A., Lenze, E. et al. The role of depression pharmacogenetic decision support tools in shared decision making. J Neural Transm 126, 87–94 (2019). https://doi.org/10.1007/s00702-017-1806-8

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  • DOI: https://doi.org/10.1007/s00702-017-1806-8

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