Abstract
We investigated whether single nucleotide polymorphisms in genes related to glucose metabolism correlate with insulin secretion in type 1 diabetes patients. A cohort of 49 type 1 diabetes patients underwent serial mixed meal tolerance tests to assess insulin secretion. Patients were genotyped for SNPs related to glucose metabolism: CDKAL1 rs7754840, G6PC2 rs560887, HHEX rs1111875, KCNJ11 rs5215. Recently diagnosed patients (<100 days) homozygous for the G allele of G6PC2 had higher area under the curve C-peptide on mixed meal tolerance tests compared to non-homozygous patients (344.8 ± 203.2 vs. 167.9 ± 131.5, p = 0.04). Other SNPs did not correlate with insulin secretion in the new onset period. In a longitudinal survival analysis, homozygosity for the minor allele (A) in G6PC2 predicted more rapid loss of insulin secretion over time. A SNP in the beta cell gene G6PC2 may correlate with preserved insulin secretion in type 1 diabetes.
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Abbreviations
- SNP:
-
Single nucleotide polymorphisms
- MMTT:
-
Mixed meal tolerance tests
- AUC:
-
Area under the curve
- IRB:
-
Institutional review board
- PCR:
-
Polymerase chain reaction
- DNA:
-
Deoxyribonucleic acid
- GWAS:
-
Genome-wide association studies
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No authors have any relevant conflict of interest to report. This study was conducted with the support of the JDRF Center for Translational Research at the Benaroya Research Institute.
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Communicated by Renato Lauro.
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Sanda, S., Wei, S., Rue, T. et al. A SNP in G6PC2 predicts insulin secretion in type 1 diabetes. Acta Diabetol 50, 459–462 (2013). https://doi.org/10.1007/s00592-012-0389-y
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DOI: https://doi.org/10.1007/s00592-012-0389-y