Abstract
Fibroblast growth factor 23 (FGF23) is an “endocrine” FGF acting in the kidney as a phosphaturic hormone and a suppressor of active vitamin D, through an inhibition of the 1α hydroxylase and a stimulation of the 24 hydroxylase. Beyond its well-known effects on the bone/kidney/parathyroid axis and its deregulation during chronic kidney disease (CKD), recent evidence has revealed its direct systemic effects on cardiovascular health. In the meantime, studies have highlighted the health implications for vitamin D inside and outside CKD that also extend beyond its classical actions on mineral homeostasis and bone metabolism: vitamin D has indeed been shown to exert pluripotent non-classical effects as a modulator of immune function in monocytes, mainly through the stimulation of the antimicrobial cathelicidin. The aim of this review is to provide new insights on the interplay between FGF23 and vitamin D in innate immunity in the context of CKD.
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Acknowledgments
This work was supported in part by educational grants (Académie Française/Jean Walter Zellidja, Réunion Pédiatrique de la Région Rhône Alpes, Société Française de Pédiatrie/Evian, Fondation pour la Recherche Médicale, Philippe Foundation, JB), by a grant from the Center for D-receptor Activation Research (CeDAR, MH), by USPHS grants DK 67563, DK 35423, DK 080984-01A1, RR 0333176–01 and funds from the Casey Lee Ball Foundation (IBS).
The authors would like to thank Katherine Wesseling-Perry, MD, Barbara Gales, RN, Joshua J Zaritsky, MD, PhD, and Renata C Pereira, PhD (Department of Pediatrics, David Geffen School of Medicine, University of California at Los Angeles, USA) for their helpful thoughts on FGF23 physiology, as well as Rene F Chun, PhD, Thomas S Lisse, PhD, and Jessica L Sea (Orthopaedic Research Hospital, University of California at Los Angeles, USA) for their technical help.
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Bacchetta, J., Salusky, I.B. & Hewison, M. Beyond mineral metabolism, is there an interplay between FGF23 and vitamin D in innate immunity?. Pediatr Nephrol 28, 577–582 (2013). https://doi.org/10.1007/s00467-012-2336-0
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DOI: https://doi.org/10.1007/s00467-012-2336-0