Abstract
This research aims to enhance the dissolution rate of prednisolone using sonoprecipitation method and to elucidate the mechanism of drug release. The sonoprecipitated prednisolone were tested in both liquid and solid dosage forms transformed by enhancement of prednisolone in stimulated colonic fluid (pH 7.4) was observed in the amorphous zein-coated prednisolone in solid dosage form, compared to its identical formulation in liquid dosage form as well as the pure crystalline prednisolone. Power X-ray Diffraction and Fourier Transform Infrared spectroscopies implied that the decrease in crystallinity level of sonoprecipitated nanoparticles could be primary mechanism for this improvement.
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We thank to International University and Vietnam National University—Ho Chi Minh City for supporting to our research activities.
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Nguyen, K.T. et al. (2018). Enhance the Dissolution Rate of Prednisolone by Sonoprecipitation Method. In: Vo Van, T., Nguyen Le, T., Nguyen Duc, T. (eds) 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6) . BME 2017. IFMBE Proceedings, vol 63. Springer, Singapore. https://doi.org/10.1007/978-981-10-4361-1_88
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DOI: https://doi.org/10.1007/978-981-10-4361-1_88
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