Abstract
Prednisolone, an anti-inflammatory drug with a very slight solubility (0.23 mg/mL at 25 °C), high permeability and short biological half-life (2–4 h) in oral administration was selected as the candidate drug for sustained drug release. The aim of this research is to formulate and evaluate the stable formation of oil-in-water microemulsion for enhancing the solubility of the model drug. Microemulsion containing oleic acid as oil component, Tween 20 and P188 as main surfactant and co-surfactant at different ratios were evaluated. The microemulsion was characterized by stability test, particle size, clarity, conductivity and pH value. A stable system at nano size (11.6 and 12.3 nm) which possibly enhanced drug solubility with no drug aggregation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ulbrich W, Lamprecht A (2009) Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases. J R Soc Interface rsif20090285
Kumria R, Nair AB, Goomber G, Gupta S (2014) Buccal films of prednisolone with enhanced bioavailability. Drug Deliv 1–8
Jha SK (2012) Microemulsions-potential carrier for improved drug delivery. Asian J Biomed Pharm Sci 1:39–51
Kwak JC (1998) Polymer-surfactant systems, vol 77. CRC Press, Boca Raton
Sarkhejiya Naimish A, Nakum Mayur A, Patel Vipul P, Atara Samir A, Desai Thusarbindu R (2000) Emerging trend of microemulsion in formulation and research. Int Bull Drug Res 1:54–83
Rasal A, Mahajan H, Shaikh H, Surana S (2010) Development and characterization of nasal mucoadhesive microemulsion of sumatriptan succinate. Indian J Novel Drug Deliv 2:103–108
Nirmala MJ, Mukherjee A, Chandrasekaran N (2012) Enhanced solubilization of aqueous insoluble anti-hypertensive drug. Int J Pharm Pharm Sci 4:366–368
Sabale V, Vora S (2012) Formulation and evaluation of microemulsion-based hydrogel for topical delivery. Int j pharm inv 2:140
Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M (2007) Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm 66:227–243
Yadav S, Khatri J, Bhalerao S (2012) Development and evaluation of an ocular anti-inflammatory microemulsion. Int J Pharm Technol 4:4218–4230
Boonme P, Krauel K, Graf A, Rades T, Junyaprasert VB (2006) Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitate/water/Brij 97: 1-butanol. AAPS PharmSciTech 7:E99–E104
Agrawal OP, Agrawal S (2012) An overview of new drug delivery system: microemulsion. Asian J Pharm Sci Tech 2(1):5–12
Wang Z, Mu H-J, Zhang X-M, Ma P-K, Lian S-N, Zhang F-P et al (2015) Lower irritation microemulsion-based rotigotine gel: formulation optimization and in vitro and in vivo studies. Int J Nanomed 10:633
Acknowledgements
This research is partially funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 106-YS.05-2015.02. We also thank to International University and Vietnam National University—Ho Chi Minh City for supporting to our research activities.
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Pham, M.N., Vo Van, T., Tran, P.HL., Tran, T.TD. (2018). Development of Microemulsion Containing Prednisolone. In: Vo Van, T., Nguyen Le, T., Nguyen Duc, T. (eds) 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6) . BME 2017. IFMBE Proceedings, vol 63. Springer, Singapore. https://doi.org/10.1007/978-981-10-4361-1_86
Download citation
DOI: https://doi.org/10.1007/978-981-10-4361-1_86
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-4360-4
Online ISBN: 978-981-10-4361-1
eBook Packages: EngineeringEngineering (R0)