Abstract
Zein was investigated in this study as a coating material for colon specific delivery of prednisolone. To strengthen the ability of film layer in the protection of a dosage form, Kollicoat® MAE 100P was investigated together with zein in an appropriate ratio. Interactions between these materials were evaluated by Fourier Transform Infrared spectroscopy (FTIR). Through the simulated gastrointestinal (GI) environment, the coated tablets released drug immediately after passing the intestinal medium. Zein was proved to be a potential coating material for a delayed release of drug to colon. FTIR spectra indicated that zein and Kollicoat® MAE 100P had only physical interactions at different ratios. Various parameters should be critically controlled in the preparation process to achieve the colon drug delivery. This work may contribute to new applications of zein for attempts of pharmaceutical scientists to design oral controlled drug release dosage forms.
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Acknowledgements
This research is partially funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 106-YS.05-2015.02. We also thank to International University and Vietnam National University—Ho Chi Minh City for supporting to our research activities.
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Nguyen, M.NU., Vo Van, T., Tran, P.HL., Tran, TD. (2018). Development of a Zein-Based System for Colon Specific Delivery. In: Vo Van, T., Nguyen Le, T., Nguyen Duc, T. (eds) 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6) . BME 2017. IFMBE Proceedings, vol 63. Springer, Singapore. https://doi.org/10.1007/978-981-10-4361-1_85
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DOI: https://doi.org/10.1007/978-981-10-4361-1_85
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