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Peptides and Peptide-based Biomaterials and their Biomedical Applications pp 95–129Cite as

Bioprinting and Biofabrication with Peptide and Protein Biomaterials

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1030))

Abstract

The ability to fabricate artificial tissue constructs through the controlled organisation of cells, structures and signals within a biomimetic scaffold offers significant promise to the field of regenerative medicine, drug delivery and tissue engineering. Advances in additive manufacturing technologies have facilitated the printing of spatially defined cell-laden artificial tissue constructs capable of providing biomimetic spatiotemporal presentation of biological and physical cues to cells in a designed multicomponent structure. Despite significant progress in the field of bioprinting, a key challenge remains in developing and utilizing materials that can adequately recapitulate the complexities of the native extracellular matrix on a nanostructured, chemical level during the printing process. This gives rise to the need for suitable materials - particularly in establishing effective control over cell fate, tissue vascularization and innervation. Recently, significant interested has been invested into developing candidate materials using protein and peptide-derived biomaterials. The ability of these materials to form highly printable hydrogels which are reminiscent of the native ECM has seen significant use in a variety of regenative applications, including both organ bioprinting and non-organ bioprinting. Here, we discuss the emerging technologies for peptide-based bioprinting applications, highlighting bioink development and detailing bioprinter processors. Furthermore, this work presents application specific, peptide-based bioprinting approaches, and provides insight into current limitations and future perspectives of peptide-based bioprinting techniques.

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Abbreviations

μCT:

Micro computed tomography

10 T1/2 :

Mouse embryo fibroblasts

ADSC:

Adipose derived stromal cells

AFA-LIFT:

absorbing film-assisted laser-induced forward transfer

B16:

Carcinoma cell line

BMSC:

Bone marrow derived mesenchymal stem cells

C2C12:

C2C12 myoblast cells

CaCl2 :

Calcium chloride

CB[6]:

Cucurbit[6]uril

DAH-HA:

1,6-diaminohexane (DAH)-conjugated HA

dECM:

Decellularized extracellular matrix

DPBS:

Dulbecco’s phosphate-buffered saline solution

ECM:

Extracellular Matrix

GAG:

Glycosaminoglycan

GelMA:

Gelatin methacryloyl

GG:

Gellan gum

H1ESCs:

H1 embryonic stem cells

HA:

Hyaluronic acid

HAC:

Human articular chondrocytes

HAp:

Hydroxyapatite

hASC:

Human adipose-derived stem cells

HAVIC:

Human aortic Valvular Interstitial cells

hCPC:

Human cardiac progenitor cells

HEK293:

Human embryonic kidney cell line

HepG2/C3A:

Human liver cancer cells (hepatocellular carcinoma)

hFB:

Human fibroblast cells

hKC:

Human keratinocyte cells

hMSC:

Human mesenchymal stem cells

HMVEC:

Human microvascular endothelial cells

HUVEC:

human umbilical vein endothelial cells

HNDF:

Human neonatal dermal fibroblasts

HSC:

Human bone marrow-derived mesenchymal stromal cells

hTMSC:

Human inferior turbinate-tissue derived mesenchymal stromal cells

L6:

Rat myoblast cell line

MAPLE-DW:

Matrix-Assisted Pulsed Laser Evaporation Direct Writing

MC3T3 E1:

Osteoblast precursor cells (Add to main article)

MCF-7:

Breast adenocarcinoma cells

MG63:

Osteoblast-like cells

MSC:

Mesenchymal stem cells

mTgase:

Microbial transglutaminise

NT2:

Neural cells

PBS:

Phosphate-buffered saline solution

PCL:

Polycaprolactone

PEG:

Poly(ethylene Glycol)

PEGDA:

Poly(ethylene Glycol)-di-acrylate

PEGDMA:

Poly(ethylene glycol) dimethacrylate

PEGMA:

Poly(ethylene glycol) methacrylate

PEGTA:

Poly(ethylene glycol)-tetra-acrylate

PEO:

Poly(ethylene oxide)

PLA:

Polylactic acid

PVA:

Polyvinyl alcohol

Ru/SPS:

Ruthenium/Sodium persulfate

SAP:

Self-Assembled Peptide

SF-G:

Silk-fibroin/Gelatin

SLA:

Stereolithography

SMC:

Smooth muscle cells

SPPS:

Solid phase peptide synthesis

TGF-β:

Transforming growth factor-β

VEGF:

Vascular endothelial growth factor

VIC:

Aortic valve leaflet interstitial cells

References

  • Almany L, Seliktar D (2005) Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures. Biomaterials 26:2467–2477

    Article  CAS  PubMed  Google Scholar 

  • Bammesberger SB, Kartmann S, Tanguy L, Liang D, Mutschler K, Ernst A, Zengerle R, Koltay P (2013) A low-cost, normally closed, solenoid valve for non-contact dispensing in the sub-μL range. Micromachines 4:9–21

    Article  Google Scholar 

  • Bhise NS, Manoharan V, Massa S, Tamayol A, Ghaderi M, Miscuglio M, Lang Q, Zhang YS, Shin SR, Calzone G (2016) A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication 8:014101

    Article  PubMed  CAS  Google Scholar 

  • Bhosale AM, Richardson JB (2008) Articular cartilage: structure, injuries and review of management. Br Med Bull 87:77–95

    Article  PubMed  Google Scholar 

  • Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN (2014) Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep 14:1–11

    Article  CAS  Google Scholar 

  • Böttcher-Haberzeth S, Biedermann T, Reichmann E (2010) Tissue engineering of skin. Burns 36:450–460

    Article  PubMed  Google Scholar 

  • Brown AC, Barker TH (2014) Fibrin-based biomaterials: modulation of macroscopic properties through rational design at the molecular level. Acta Biomater 10:1502–1514

    Article  CAS  PubMed  Google Scholar 

  • Bruggeman KF, Rodriguez AL, Parish CL, Williams RJ, Nisbet DR (2016) Temporally controlled release of multiple growth factors from a self-assembling peptide hydrogel. Nanotechnology 27:385102

    Article  PubMed  CAS  Google Scholar 

  • Buenger D, Topuz F, Groll J (2012) Hydrogels in sensing applications. Prog Polym Sci 37:1678–1719

    Article  CAS  Google Scholar 

  • Burg KJ, Porter S, Kellam JF (2000) Biomaterial developments for bone tissue engineering. Biomaterials 21:2347–2359

    Article  CAS  PubMed  Google Scholar 

  • Chen F-M, Liu X (2016) Advancing biomaterials of human origin for tissue engineering. Prog Polym Sci 53:86–168

    Article  CAS  PubMed  Google Scholar 

  • Chimene D, Lennox KK, Kaunas RR, Gaharwar AK (2016) Advanced bioinks for 3D printing: a materials science perspective. Ann Biomed Eng 44:2090–2102

    Article  PubMed  Google Scholar 

  • Choi YJ, Kim TG, Jeong J, Yi HG, Park JW, Hwang W, Cho DW (2016) 3D cell printing of functional skeletal muscle constructs using skeletal muscle–derived bioink. Adv Healthc Mater 5:2636–2645

    Article  CAS  PubMed  Google Scholar 

  • Collins MN, Birkinshaw C (2013) Hyaluronic acid based scaffolds for tissue engineering—a review. Carbohydr Polym 92:1262–1279

    Article  CAS  PubMed  Google Scholar 

  • Crapo PM, Gilbert TW, Badylak SF (2011) An overview of tissue and whole organ decellularization processes. Biomaterials 32:3233–3243

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cubo N, Garcia M, del Cañizo JF, Velasco D, Jorcano JL (2016) 3D bioprinting of functional human skin: production and in vivo analysis. Biofabrication 9:015006

    Article  PubMed  Google Scholar 

  • Cui X, Boland T (2009) Human microvasculature fabrication using thermal inkjet printing technology. Biomaterials 30:6221–6227

    Article  CAS  PubMed  Google Scholar 

  • Cui H, Nowicki M, Fisher JP, Zhang LG (2017) 3D bioprinting for organ regeneration. Adv Healthc Mater 6:1601118

    Article  CAS  Google Scholar 

  • Daly AC, Critchley SE, Rencsok EM, Kelly DJ (2016) A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage. Biofabrication 8:045002

    Article  PubMed  Google Scholar 

  • Das S, Pati F, Choi Y-J, Rijal G, Shim J-H, Kim SW, Ray AR, Cho D-W, Ghosh S (2015) Bioprintable, cell-laden silk fibroin–gelatin hydrogel supporting multilineage differentiation of stem cells for fabrication of three-dimensional tissue constructs. Acta Biomater 11:233–246

    Article  CAS  PubMed  Google Scholar 

  • de la Puente P, Ludeña D (2014) Cell culture in autologous fibrin scaffolds for applications in tissue engineering. Exp Cell Res 322:1–11

    Article  PubMed  CAS  Google Scholar 

  • Dikovsky D, Bianco-Peled H, Seliktar D (2006) The effect of structural alterations of PEG-fibrinogen hydrogel scaffolds on 3-D cellular morphology and cellular migration. Biomaterials 27:1496–1506

    Article  CAS  PubMed  Google Scholar 

  • Doolittle RF (2001) Fibrinogen and fibrin. In: eLS. Wiley, Chichester

    Google Scholar 

  • Duan B (2017) State-of-the-art review of 3D bioprinting for cardiovascular tissue engineering. Ann Biomed Eng 45:195–209

    Article  PubMed  Google Scholar 

  • Duan B, Hockaday LA, Kang KH, Butcher JT (2013) 3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels. J Biomed Mater Res A 101:1255–1264

    Article  PubMed  CAS  Google Scholar 

  • Duan B, Kapetanovic E, Hockaday LA, Butcher JT (2014) Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells. Acta Biomater 10:1836–1846

    Article  CAS  PubMed  Google Scholar 

  • Duarte Campos DF, Blaeser A, Buellesbach K, Sen KS, Xun W, Tillmann W, Fischer H (2016) Bioprinting organotypic hydrogels with improved mesenchymal stem cell remodeling and mineralization properties for bone tissue engineering. Adv Healthc Mater 5:1336–1345

    Article  CAS  PubMed  Google Scholar 

  • Dubbin K, Hori Y, Lewis KK, Heilshorn SC (2016) Dual-stage crosslinking of a gel-phase bioink improves cell viability and homogeneity for 3D bioprinting. Adv Healthc Mater 5:2488–2492

    Article  CAS  PubMed  Google Scholar 

  • Einerson NJ, Stevens KR, Kao WJ (2003) Synthesis and physicochemical analysis of gelatin-based hydrogels for drug carrier matrices. Biomaterials 24:509–523

    Article  CAS  PubMed  Google Scholar 

  • England S, Rajaram A, Schreyer DJ, Chen X (2017) Bioprinted fibrin-factor XIII-hyaluronate hydrogel scaffolds with encapsulated Schwann cells and their in vitro characterization for use in nerve regeneration. Bioprinting 5:1–9

    Article  Google Scholar 

  • Ferris CJ, Gilmore KG, Wallace GG (2013) Biofabrication: an overview of the approaches used for printing of living cells. App Microbiol Biotechnol 97:4243–4258

    Article  CAS  Google Scholar 

  • Fortunato TM, Beltrami C, Emanueli C, De Bank PA, Pula G (2016) Platelet lysate gel and endothelial progenitors stimulate microvascular network formation in vitro: tissue engineering implications. Sci Rep 6:25326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gao G, Cui X (2016) Three-dimensional bioprinting in tissue engineering and regenerative medicine. Biotechnol Lett 38:203–211

    Article  CAS  PubMed  Google Scholar 

  • Gao G, Schilling AF, Hubbell K, Yonezawa T, Truong D, Hong Y, Dai G, Cui X (2015a) Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA. Biotechnol Lett 37:2349–2355

    Article  CAS  PubMed  Google Scholar 

  • Gao G, Yonezawa T, Hubbell K, Dai G, Cui X (2015b) Inkjet-bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging. Biotechnol J 10:1568–1577

    Article  CAS  PubMed  Google Scholar 

  • García-Martínez L, Campos F, Godoy-Guzmán C, del Carmen S-QM, Garzón I, Alaminos M, Campos A, Carriel V (2017) Encapsulation of human elastic cartilage-derived chondrocytes in nanostructured fibrin-agarose hydrogels. Histochem Cell Biol 147:83–95

    Article  PubMed  CAS  Google Scholar 

  • Gilbert TW, Sellaro TL, Badylak SF (2006) Decellularization of tissues and organs. Biomaterials 27:3675–3683

    CAS  PubMed  Google Scholar 

  • Guillemot F, Guillotin B, Fontaine A, Ali M, Catros S, Kériquel V, Fricain J-C, Rémy M, Bareille R, Amédée-Vilamitjana J (2011) Laser-assisted bioprinting to deal with tissue complexity in regenerative medicine. MRS Bull 36:1015–1019

    Article  CAS  Google Scholar 

  • Guillotin B, Souquet A, Catros S, Duocastella M, Pippenger B, Bellance S, Bareille R, Rémy M, Bordenave L, Amédée J, Guillemot F (2010) Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials 31:7250–7256

    Article  CAS  PubMed  Google Scholar 

  • Guo B, Ma PX (2014) Synthetic biodegradable functional polymers for tissue engineering: a brief review. Sci China Chem 57:490–500

    Article  CAS  Google Scholar 

  • Gurkan UA, El Assal R, Yildiz SE, Sung Y, Trachtenberg AJ, Kuo WP, Demirci U (2014) Engineering anisotropic biomimetic fibrocartilage microenvironment by bioprinting mesenchymal stem cells in nanoliter gel droplets. Mol Pharm 11:2151–2159

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guvendiren M, Burdick JA (2013) Engineering synthetic hydrogel microenvironments to instruct stem cells. Curr Opin Biotechnol 24:841–846

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hölzl K, Lin S, Tytgat L, Van Vlierberghe S, Gu L, Ovsianikov A (2016) Bioink properties before, during and after 3D bioprinting. Biofabrication 8:032002

    Article  PubMed  CAS  Google Scholar 

  • Horgan CC, Rodriguez AL, Li R, Bruggeman KF, Stupka N, Raynes JK, Day L, White JW, Williams RJ, Nisbet DR (2016) Characterisation of minimalist co-assembled fluorenylmethyloxycarbonyl self-assembling peptide systems for presentation of multiple bioactive peptides. Acta Biomater 38:11–22

    Article  CAS  PubMed  Google Scholar 

  • Hsieh JY, Smith TD, Meli VS, Tran TN, Botvinick EL, Liu WF (2017) Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen. Acta Biomater 47:14–24

    Article  CAS  PubMed  Google Scholar 

  • Huang SH, Liu P, Mokasdar A, Hou L (2013) Additive manufacturing and its societal impact: a literature review. Int J Adv Manuf Technol 67:1191–1203

    Article  Google Scholar 

  • Hunt JA, Chen R, van Veen T, Bryan N (2014) Hydrogels for tissue engineering and regenerative medicine. J Mater Chem B 2:5319–5338

    Article  CAS  Google Scholar 

  • Irvine SA, Agrawal A, Lee BH, Chua HY, Low KY, Lau BC, Machluf M, Venkatraman S (2015) Printing cell-laden gelatin constructs by free-form fabrication and enzymatic protein crosslinking. Biomed Microdevices 17:1–8

    Article  CAS  Google Scholar 

  • Jang J, Kim TG, Kim BS, Kim S-W, Kwon S-M, Cho D-W (2016) Tailoring mechanical properties of decellularized extracellular matrix bioink by vitamin B2-induced photo-crosslinking. Acta Biomater 33:88–95

    Article  CAS  PubMed  Google Scholar 

  • Jang J, Park H-J, Kim S-W, Kim H, Park JY, Na SJ, Kim HJ, Park MN, Choi SH, Park SH, Kim SW, Kwon S-M, Kim P-J, Cho D-W (2017) 3D printed complex tissue construct using stem cell-laden decellularized extracellular matrix bioinks for cardiac repair. Biomaterials 112:264–274

    Article  CAS  PubMed  Google Scholar 

  • Jia W, Gungor-Ozkerim PS, Zhang YS, Yue K, Zhu K, Liu W, Pi Q, Byambaa B, Dokmeci MR, Shin SR, Khademhosseini A (2016) Direct 3D bioprinting of perfusable vascular constructs using a blend bioink. Biomaterials 106:58–68

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jungst T, Smolan W, Schacht K, Scheibel T, Jr G (2016) Strategies and molecular design criteria for 3D printable hydrogels. Chem Rev 116:1496–1539

    Article  CAS  PubMed  Google Scholar 

  • Kamisuki S, Hagata T, Tezuka C, Nose Y, Fujii M, Atobe M (1998) A low power, small, electrostatically-driven commercial inkjet head. Proceed IEEE MEMS’ 98:63–68

    Google Scholar 

  • Karlsen TA, Jakobsen RB, Brinchmann JE (2016) Early molecular events during in vitro chondrogenesis. In: Atkinson K (ed) The biology and therapeutic application of mesenchymal cells. Wiley, Hoboken

    Google Scholar 

  • Kasoju N, Bora U (2012) Silk fibroin in tissue engineering. Adv Healthc Mater 1:393–412

    Article  CAS  PubMed  Google Scholar 

  • Kim YB, Lee H, Kim GH (2016) Strategy to achieve highly porous/biocompatible macroscale cell blocks, using a collagen/genipin-bioink and an optimal 3D printing process. ACS Appl Mater Interfaces 8:32230–32240

    Article  CAS  PubMed  Google Scholar 

  • Kolesky DB, Truby RL, Gladman A, Busbee TA, Homan KA, Lewis JA (2014) 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Adv Mater 26:3124–3130

    Article  CAS  PubMed  Google Scholar 

  • Kundu B, Rajkhowa R, Kundu SC, Wang X (2013) Silk fibroin biomaterials for tissue regenerations. Adv Drug Deliv Rev 65:457–470

    Article  CAS  PubMed  Google Scholar 

  • Lau HK, Kiick KL (2014) Opportunities for multicomponent hybrid hydrogels in biomedical applications. Biomacromolecules 16:28–42

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lee KY, Mooney DJ (2001) Hydrogels for tissue engineering. Chem Rev 101:1869–1880

    Article  CAS  PubMed  Google Scholar 

  • Lee CH, Singla A, Lee Y (2001) Biomedical applications of collagen. Int J Pharm 221:1–22

    Article  CAS  PubMed  Google Scholar 

  • Lee HJ, Kim YB, Ahn SH, Lee JS, Jang CH, Yoon H, Chun W, Kim GH (2015) A new approach for fabricating collagen/ecm-based bioinks using preosteoblasts and human adipose stem cells. Adv Healthc Mater 4:1359–1368

    Article  CAS  PubMed  Google Scholar 

  • Levato R, Visser J, Planell JA, Engel E, Malda J, Mateos-Timoneda MA (2014) Biofabrication of tissue constructs by 3D bioprinting of cell-laden microcarriers. Biofabrication 6:035020

    Article  PubMed  CAS  Google Scholar 

  • Lewis MP, Mudera V, Cheema U, Shah R (2009) Muscle tissue engineering. In: Meyer U, Meyer T, Handschel J, Wiesmann HP (eds) Fundamentals of tissue engineering and regenerative medicine. Springer, Berlin/Heidelberg

    Google Scholar 

  • Li S, Xiong Z, Wang X, Yan Y, Liu H, Zhang R (2009) Direct fabrication of a hybrid cell/hydrogel construct by a double-nozzle assembling technology. J Bioact Compat Polym 24:249–265

    Article  CAS  Google Scholar 

  • Li R, Rodriguez A, Nisbet DR, Barrow CJ, Williams RJ (2015) Self-assembled peptide nanostructures for the fabrication of cell scaffolds. In: Castillo-Leon J, Svendsen WE (eds) Micro and nanofabrication using self-assembled biological nanostructures. Elsevier, Amsterdam

    Google Scholar 

  • Lim KS, Schon BS, Mekhileri NV, Brown GC, Chia CM, Prabakar S, Hooper GJ, Woodfield TB (2016) New visible-light photoinitiating system for improved print fidelity in gelatin-based bioinks. ACS Biomater Sci Eng 2:1752–1762

    Article  CAS  Google Scholar 

  • Loo Y, Lakshmanan A, Ni M, Toh LL, Wang S, Hauser CA (2015) Peptide bioink: self-assembling nanofibrous scaffolds for three-dimensional organotypic cultures. Nano Lett 15:6919–6925

    Article  CAS  PubMed  Google Scholar 

  • Lynn A, Yannas I, Bonfield W (2004) Antigenicity and immunogenicity of collagen. J Biomed Mater Res B Appl Biomater 71:343–354

    Article  CAS  PubMed  Google Scholar 

  • MacNeil S (2007) Progress and opportunities for tissue-engineered skin. Nature 445:874–880

    Article  CAS  PubMed  Google Scholar 

  • Murphy SV, Atala A (2014) 3D bioprinting of tissues and organs. Nat Biotechnol 32:773–785

    Article  CAS  PubMed  Google Scholar 

  • Nerem RM, Seliktar D (2001) Vascular tissue engineering. Annu Rev Biomed Eng 3:225–243

    Article  CAS  PubMed  Google Scholar 

  • Nilasaroya A, Poole-Warren LA, Whitelock JM, Martens PJ (2008) Structural and functional characterisation of poly (vinyl alcohol) and heparin hydrogels. Biomaterials 29:4658–4664

    Article  CAS  PubMed  Google Scholar 

  • Nisbet DR, Williams RJ (2012) Self-assembled peptides: characterisation and in vivo response. Biointerphases 7:2

    Article  CAS  PubMed  Google Scholar 

  • Nishiyama Y, Henmi C, Iwanaga S, Nakagawa H, Yamaguchi K, Akita K, Mochizuki S, Takiura K, Nakamura M (2008) Ink jet three-dimensional digital fabrication for biological tissue manufacturing: analysis of alginate microgel beads produced by ink jet droplets for three dimensional tissue fabrication. J Imaging Sci Technol 52:60201–60201–60201–60206

    Google Scholar 

  • Novosel EC, Kleinhans C, Kluger PJ (2011) Vascularization is the key challenge in tissue engineering. Adv Drug Deliv Rev 63:300–311

    Article  CAS  PubMed  Google Scholar 

  • Nukavarapu SP, Dorcemus DL (2013) Osteochondral tissue engineering: current strategies and challenges. Biotechnol Adv 31:706–721

    Article  CAS  PubMed  Google Scholar 

  • Odde DJ, Renn MJ (1999) Laser-guided direct writing for applications in biotechnology. Trends Biotechnol 17:385–389

    Article  CAS  PubMed  Google Scholar 

  • Odde DJ, Renn MJ (2000) Laser-guided direct writing of living cells. Biotechnol Bioeng 67:312–318

    Article  CAS  PubMed  Google Scholar 

  • Olszta MJ, Cheng X, Jee SS, Kumar R, Kim Y-Y, Kaufman MJ, Douglas EP, Gower LB (2007) Bone structure and formation: a new perspective. Mater Sci Eng R Rep 58:77–116

    Article  CAS  Google Scholar 

  • Ozbolat IT, Hospodiuk M (2016) Current advances and future perspectives in extrusion-based bioprinting. Biomaterials 76:321–343

    Article  CAS  PubMed  Google Scholar 

  • Ozbolat IT, Moncal KK, Gudapati H (2017) Evaluation of bioprinter technologies. Addit Manuf 13:179–200

    Article  CAS  Google Scholar 

  • Park JY, Gao G, Jang J, Cho D-W (2016) 3D printed structures for delivery of biomolecules and cells: tissue repair and regeneration. J Mater Chem B 4:7521–7539

    Article  CAS  Google Scholar 

  • Pati F, Jang J, Ha D-H, Kim SW, Rhie J-W, Shim J-H, Kim D-H, Cho D-W (2014) Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink. Nat Commun 5:3935

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pugsley MK, Tabrizchi R (2000) The vascular system: an overview of structure and function. J Pharmacol Toxicol Methods 44:333–340

    Article  CAS  PubMed  Google Scholar 

  • Ren X, Wang F, Chen C, Gong X, Yin L, Yang L (2016) Engineering zonal cartilage through bioprinting collagen type II hydrogel constructs with biomimetic chondrocyte density gradient. BMC Musculoskelet Disord 17:301

    Article  PubMed  PubMed Central  Google Scholar 

  • Rhee S, Puetzer JL, Mason BN, Reinhart-King CA, Bonassar LJ (2016) 3D bioprinting of spatially heterogeneous collagen constructs for cartilage tissue engineering. ACS Biomater Sci Eng 2:1800–1805

    Article  CAS  Google Scholar 

  • Rice JJ, Martino MM, De Laporte L, Tortelli F, Briquez PS, Hubbell JA (2013) Engineering the regenerative microenvironment with biomaterials. Adv Healthc Mater 2:57–71

    Article  CAS  PubMed  Google Scholar 

  • Richards D, Jia J, Yost M, Markwald R, Mei Y (2017) 3D bioprinting for vascularized tissue fabrication. Ann Biomed Eng 45:132–147

    Article  PubMed  Google Scholar 

  • Rodriguez A, Wang T-Y, Bruggeman K, Horgan C, Li R, Williams RJ, Parish CL, Nisbet D (2014) In vivo assessment of grafted cortical neural progenitor cells and host response to functionalized self-assembling peptide hydrogels and the implications for tissue repair. J Mater Chem B 2:7771–7778

    Article  CAS  Google Scholar 

  • Sadtler K, Singh A, Wolf MT, Wang X, Pardoll DM, Elisseeff JH (2016) Design, clinical translation and immunological response of biomaterials in regenerative medicine. Nat Rev Mater 1:16040

    Article  CAS  Google Scholar 

  • Sargeant TD, Desai AP, Banerjee S, Agawu A, Stopek JB (2012) An in situ forming collagen–PEG hydrogel for tissue regeneration. Acta Biomater 8:124–132

    Article  CAS  PubMed  Google Scholar 

  • Schiaffino S, Reggiani C (2011) Fiber types in mammalian skeletal muscles. Physiol Rev 91:1447–1531

    Article  CAS  PubMed  Google Scholar 

  • Schiele NR, Corr DT, Huang Y, Raof NA, Xie Y, Chrisey DB (2010) Laser-based direct-write techniques for cell printing. Biofabrication 2:032001

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Schmidt CE, Leach JB (2003) Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 5:293–347

    Article  CAS  PubMed  Google Scholar 

  • Sehnal F, Žurovec M (2004) Construction of silk fiber core in Lepidoptera. Biomacromolecules 5:666–674

    Article  CAS  PubMed  Google Scholar 

  • Shim J-H, Jang K-M, Hahn SK, Park JY, Jung H, Oh K, Park KM, Yeom J, Park SH, Kim SW (2016) Three-dimensional bioprinting of multilayered constructs containing human mesenchymal stromal cells for osteochondral tissue regeneration in the rabbit knee joint. Biofabrication 8:014102

    Article  PubMed  CAS  Google Scholar 

  • Skardal A, Atala A (2015) Biomaterials for integration with 3-D bioprinting. Ann Biomed Eng 43:730–746

    Article  PubMed  Google Scholar 

  • Skardal A, Devarasetty M, Kang H-W, Mead I, Bishop C, Shupe T, Lee SJ, Jackson J, Yoo J, Soker S, Atala A (2015) A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. Acta Biomater 25:24–34

    Article  CAS  PubMed  Google Scholar 

  • Smith AM, Williams RJ, Tang C, Coppo P, Collins RF, Turner ML, Saiani A, Ulijn RV (2008) Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on π–π interlocked β-sheets. Adv Mater 20:37–41

    Article  CAS  Google Scholar 

  • Spotnitz WD (2010) Fibrin sealant: past, present, and future: a brief review. World J Surg 34:632–634

    Article  PubMed  Google Scholar 

  • Tamada Y (2005) New process to form a silk fibroin porous 3-D structure. Biomacromolecules 6:3100–3106

    Article  CAS  PubMed  Google Scholar 

  • Tanaka K, Inoue S, Mizuno S (1999) Hydrophobic interaction of P25, containing Asn-linked oligosaccharide chains, with the H-L complex of silk fibroin produced by Bombyx mori. Insect Biochem Mol Biol 29:269–276

    Article  CAS  PubMed  Google Scholar 

  • Tang D, Tare RS, Yang L-Y, Williams DF, Ou K-L, Oreffo RO (2016) Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration. Biomaterials 83:363–382

    Article  CAS  PubMed  Google Scholar 

  • Thiagarajan P, Narayanan A (2001) Thrombin. In: eLS. John Wiley & Sons ltd, Chichester

    Google Scholar 

  • Tibbitt MW, Anseth KS (2009) Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol Bioeng 103:655–663

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vaezi M, Seitz H, Yang S (2013) A review on 3D micro-additive manufacturing technologies. Int J Adv Manuf Technol 67:1721–1754

    Article  Google Scholar 

  • Wang Z, Abdulla R, Parker B, Samanipour R, Ghosh S, Kim K (2015) A simple and high-resolution stereolithography-based 3D bioprinting system using visible light crosslinkable bioinks. Biofabrication 7:045009

    Article  PubMed  Google Scholar 

  • Weiner S, Wagner HD (1998) The material bone: structure-mechanical function relations. Annu Rev Mater Sci 28:271–298

    Article  CAS  Google Scholar 

  • Whelan D, Caplice N, Clover A (2014) Fibrin as a delivery system in wound healing tissue engineering applications. J Control Release 196:1–8

    Article  CAS  PubMed  Google Scholar 

  • Winter JO, Schmidt CE (2002) Biomimetic strategies and applications in the nervous system. In: Dillow A, Lowman A (eds) Biomimetic materials and design: biointerfacial strategies, tissue engineering, and targeted drug delivery. Marcel-Dekker, New York

    Google Scholar 

  • Wüst S, Godla ME, Müller R, Hofmann S (2014) Tunable hydrogel composite with two-step processing in combination with innovative hardware upgrade for cell-based three-dimensional bioprinting. Acta Biomater 10:630–640

    Article  PubMed  CAS  Google Scholar 

  • Xiao W, He J, Nichol JW, Wang L, Hutson CB, Wang B, Du Y, Fan H, Khademhosseini A (2011) Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels. Acta Biomater 7:2384–2393

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu T, Gregory CA, Molnar P, Cui X, Jalota S, Bhaduri SB, Boland T (2006) Viability and electrophysiology of neural cell structures generated by the inkjet printing method. Biomaterials 27:3580–3588

    CAS  PubMed  Google Scholar 

  • Zhang X, Zhang Y (2015) Tissue engineering applications of three-dimensional bioprinting. Cell Biochem Biophys 72:777–782

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Yu Y, Akkouch A, Dababneh A, Dolati F, Ozbolat IT (2015) In vitro study of directly bioprinted perfusable vasculature conduits. Biomater Sci 3:134–143

    Article  CAS  PubMed  Google Scholar 

  • Zhang YS, Arneri A, Bersini S, Shin S-R, Zhu K, Goli-Malekabadi Z, Aleman J, Colosi C, Busignani F, Dell'Erba V, Bishop C, Shupe T, Demarchi D, Moretti M, Rasponi M, Dokmeci MR, Atala A, Khademhosseini A (2016) Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip. Biomaterials 110:45–59

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou X, Zhu W, Nowicki M, Miao S, Cui H, Holmes B, Glazer RI, Zhang LG (2016) 3D bioprinting a cell-laden bone matrix for breast cancer metastasis study. ACS Appl Mater Interfaces 8:30017–30026

    Article  CAS  PubMed  Google Scholar 

  • Zhu W, Harris BT, Zhang LG (2016) Gelatin methacrylamide hydrogel with graphene nanoplatelets for neural cell-laden 3D bioprinting. Conf Proc IEEE Eng Med Biol Soc 2016:4185–4188

    Google Scholar 

  • Zimmermann W-H, Melnychenko I, Eschenhagen T (2004) Engineered heart tissue for regeneration of diseased hearts. Biomaterials 25:1639–1647

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. School of Engineering, RMIT University, Melbourne, VIC, Australia

    Mitchell Boyd-Moss, Kate Fox, Milan Brandt & Richard Williams

  2. Biofab3D, St. Vincent’s Hospital Melbourne, Fitzroy, VIC, Australia

    Mitchell Boyd-Moss & Richard Williams

  3. Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne, VIC, Australia

    Milan Brandt

  4. Laboratory of Advanced Biomaterials, Research School of Engineering, The Australian National University, Canberra, ACT, Australia

    David Nisbet

Authors
  1. Mitchell Boyd-Moss
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  2. Kate Fox
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  3. Milan Brandt
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  4. David Nisbet
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  5. Richard Williams
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Correspondence to Richard Williams .

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Editors and Affiliations

  1. Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia

    Anwar Sunna

  2. Biomolecular Discovery and Design, Research Centre, Macquarie University, North Ryde, New South Wales, Australia

    Andrew Care

  3. Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia

    Peter L. Bergquist

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Boyd-Moss, M., Fox, K., Brandt, M., Nisbet, D., Williams, R. (2017). Bioprinting and Biofabrication with Peptide and Protein Biomaterials. In: Sunna, A., Care, A., Bergquist, P. (eds) Peptides and Peptide-based Biomaterials and their Biomedical Applications. Advances in Experimental Medicine and Biology, vol 1030. Springer, Cham. https://doi.org/10.1007/978-3-319-66095-0_5

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