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Physics of Biological Membranes pp 311–350Cite as

Membrane-Mediated Interactions

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Abstract

Interactions mediated by the cell membrane between inclusions, such as membrane proteins or antimicrobial peptides, play important roles in their biological activity. They also constitute a fascinating challenge for physicists, since they test the boundaries of our understanding of self-assembled lipid membranes, which are remarkable examples of two-dimensional complex fluids. Inclusions can couple to various degrees of freedom of the membrane, resulting in different types of interactions. In this chapter, we review the membrane-mediated interactions that arise from direct constraints imposed by inclusions on the shape of the membrane. These effects are generic and do not depend on specific chemical interactions. Hence, they can be studied using coarse-grained soft matter descriptions. We deal with long-range membrane-mediated interactions due to the constraints imposed by inclusions on membrane curvature and on its fluctuations. We also discuss the shorter-range interactions that arise from the constraints on membrane thickness imposed by inclusions presenting a hydrophobic mismatch with the membrane.

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Acknowledgements

A.-F. B. acknowledges support from the Human Frontier Science Program. D. C. and J.-B. F. acknowledge support by ANR Grant MEMINT (2012-BS04-0023).

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Authors and Affiliations

  1. Sorbonne Université, CNRS, Laboratoire Jean Perrin (UMR 8237), Paris, France

    Anne-Florence Bitbol

  2. Lewis-Sigler Institute for Integrative Genomics and Department of Physics, Princeton University, Princeton, NJ, USA

    Anne-Florence Bitbol

  3. Laboratoire de Physique des Solides, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France

    Doru Constantin

  4. Laboratoire “Matière et Systèmes Complexes” (MSC), UMR 7057 CNRS, Université Paris 7 Diderot, Paris Cedex 13, France

    Jean-Baptiste Fournier

Authors
  1. Anne-Florence Bitbol
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  2. Doru Constantin
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  3. Jean-Baptiste Fournier
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Correspondence to Anne-Florence Bitbol .

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Editors and Affiliations

  1. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Patricia Bassereau

  2. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Pierre Sens

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Bitbol, AF., Constantin, D., Fournier, JB. (2018). Membrane-Mediated Interactions. In: Bassereau, P., Sens, P. (eds) Physics of Biological Membranes. Springer, Cham. https://doi.org/10.1007/978-3-030-00630-3_13

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