Editors:
- Underlines the diagnostic and clinical importance of this family of proteins in human diseases
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 963)
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Table of contents (25 protocols)
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Front Matter
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Intracellular Ca2+-Measurements and Cation Interactions with EF-Hand Proteins
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Front Matter
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Intracellular Ca2+- Measurements and Cation Interactions with EF—Hand Proteins
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Expression, Purification, Biochemical, and Structural Analyses and Cellular Localization
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Front Matter
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Interaction of Ca2+-Binding Proteins with Targets and Receptors/RAGE
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Front Matter
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RAGE-Meditated Cell Signaling and Pathology
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Front Matter
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RAGE-Meditated CELL Signalling and Pathology
About this book
A major direction in medical research leading to clinical applications targets the regulation of intracellular calcium and the various human diseases associated with an altered homeostasis of this global second messenger. These diseases include, for example: cardiomyopathy, inflammation, brain disorders, diabetes and cancer. In Calcium-Binding Proteins and RAGE: from Structural Basics to Clinical Applications,expert researchers in the field detail many of the methods which are now commonly used to study calcium binding proteins. These methods and techniques, such as calcium-measurements, screening methods, clinical chemistry, and therapy, are generally applicable to many other areas of basic and medical research as well as to diagnostics. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical,Calcium-Binding Proteins and RAGE: from Structural Basics to Clinical Applications underlines the diagnostic and clinical importance of this family of proteins in human diseases and as drug targets.
Editors and Affiliations
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Div of Clinical Chem & Biochem, Department of Pediatrics, University of Zürich, Zürich, Switzerland
Claus W. Heizmann
Bibliographic Information
Book Title: Calcium-Binding Proteins and RAGE
Book Subtitle: From Structural Basics to Clinical Applications
Editors: Claus W. Heizmann
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-62703-230-8
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2013
Hardcover ISBN: 978-1-62703-229-2Published: 08 January 2013
Softcover ISBN: 978-1-4939-5976-1Published: 23 August 2016
eBook ISBN: 978-1-62703-230-8Published: 09 January 2013
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XIV, 424
Topics: Protein Science, Protein Structure