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Computer-Aided Tissue Engineering pp 269–287Cite as

Graft–Artery Junctions: Design Optimization and CAD Development

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 868))

Abstract

Designing and manufacturing of vascular prosthesis for arterial bypass grafts is a very complex problem. The process involves the selection of suitable geometry, materials of appropriate characteristics, and manufacturing technique capable of constructing prosthesis in a cost-effective manner. In this chapter, all engineering aspects related to the design and optimization of an artificial graft are presented and discussed. These aspects include CAD design of the graft, in vitro hemodynamic analysis to ensure good mechanical integrity and functionality, and optimization of the manufacturing techniques. Brief discussion is also given on the endothelization and vascularization of the artificial vessels and the future directions of the development of synthetic vessels for human implementation.

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Authors and Affiliations

  1. Biomechanics and Tissue Engineering Group, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Melbourne, Australia

    Yos S. Morsi, Amal Ahmed Owida, Hung Do & Md. Shamsul Arefin

  2. Centre for Material and Fibre Innovation, ITRI, Deakin University, Melbourne, Australia

    Xungai Wang

Authors
  1. Yos S. Morsi
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  2. Amal Ahmed Owida
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  3. Hung Do
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  4. Md. Shamsul Arefin
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  5. Xungai Wang
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Corresponding author

Correspondence to Yos S. Morsi .

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Editors and Affiliations

  1. , Department of Neurosurgery, Baylor College of Medicine, Holcombe Blvd. 2002, Houston, 77030, Texas, USA

    Michael A.K. Liebschner

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Morsi, Y.S., Owida, A.A., Do, H., Arefin, M.S., Wang, X. (2012). Graft–Artery Junctions: Design Optimization and CAD Development. In: Liebschner, M. (eds) Computer-Aided Tissue Engineering. Methods in Molecular Biology, vol 868. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-764-4_16

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  • DOI: https://doi.org/10.1007/978-1-61779-764-4_16

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-763-7

  • Online ISBN: 978-1-61779-764-4

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